Cell Biology Antibodies 1
Anti-CORIN Antibody (CAB10404)
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- SKU:
- CAB10404
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CORIN Antibody |
| Antibody SKU: | CAB10404 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human CORIN (NP_006578.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Hela, HT-1080, Mouse heart, Mouse brain, Rat heart, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human CORIN (NP_006578.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKQS PALA PEER CRRA GSPK PVLR ADDN NMGN GCSQ KLAT ANLL RFLL LVLI PCIC ALVL LLVI LLSY VGTL QKVY FKSN GSEP LVTD GEIQ GSDV ILTN TIYN QSTV VS |
| Gene ID: | 10699 |
| Uniprot: | Q9Y5Q5 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein |
| Calculated MW: | 113kDa/116kDa |
| Observed MW: | 116kDa |
| Synonyms: | CORIN, ATC2, CRN, Lrp4, PEE5, TMPRSS10, corin |
| Background: | This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CORIN: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Defects in CORIN are the cause of pre-eclampsia/eclampsia 5 (PEE5); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.21.-; Membrane protein, integral; Cell surface; Protease Chromosomal Location of Human Ortholog: 4p12 Cellular Component: plasma membrane Molecular Function:serine-type endopeptidase activity Biological Process: female pregnancy; peptide hormone processing; regulation of blood pressure; regulation of systemic arterial blood pressure by atrial natriuretic peptide Disease: Preeclampsia/eclampsia 5 |
| NCBI Summary: | This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q9Y5Q5 |
| NCBI GenInfo Identifier: | 317373348 |
| NCBI Gene ID: | 10699 |
| NCBI Accession: | Q9Y5Q5.2 |
| UniProt Secondary Accession: | Q9Y5Q5,Q2TBD2, Q4W5E5, Q4W5G6, Q9UHY2, B0ZBE3, |
| UniProt Related Accession: | Q9Y5Q5 |
| Molecular Weight: | 113,297 Da |
| NCBI Full Name: | Atrial natriuretic peptide-converting enzyme |
| NCBI Synonym Full Names: | corin, serine peptidase |
| NCBI Official Symbol: | CORIN |
| NCBI Official Synonym Symbols: | CRN; ATC2; Lrp4; PEE5; TMPRSS10 |
| NCBI Protein Information: | atrial natriuretic peptide-converting enzyme |
| UniProt Protein Name: | Atrial natriuretic peptide-converting enzyme |
| UniProt Synonym Protein Names: | Corin; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme; Transmembrane protease serine 10 |
| Protein Family: | Atrial natriuretic peptide-converting enzyme |
| UniProt Gene Name: | CORIN |
| UniProt Entry Name: | CORIN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CORIN antibody (CAB10404) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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