Metabolism Antibodies 2
Anti-COQ7 Antibody (CAB7768)
- SKU:
- CAB7768
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-COQ7 Antibody |
| Antibody SKU: | CAB7768 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-217 of human COQ7 (NP_057222.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-217 of human COQ7 (NP_057222.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SGMT LDNI SRAA VDRI IRVD HAGE YGAN RIYA GQMA VLGR TSVG PVIQ KMWD QEKD HLKK FNEL MVTF RVRP TVLM PLWN VLGF ALGA GTAL LGKE GAMA CTVA VEES IAHH YNNQ IRTL MEED PEKY EELL QLIK KFRD EELE HHDI GLDH DAEL APAY AVLK SIIQ AGCR VAIY LSER L |
| Gene ID: | 10229 |
| Uniprot: | Q99807 |
| Cellular Location: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein |
| Calculated MW: | 20kDa/24kDa |
| Observed MW: | 26kDa |
| Synonyms: | COQ7, CAT5, CLK-1, CLK1, COQ10D8, coenzyme Q7 |
| Background: | The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | COQ7: Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator. Belongs to the COQ7 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Mitochondrial Chromosomal Location of Human Ortholog: 16p12.3 Cellular Component: mitochondrial inner membrane; nucleus Molecular Function:metal ion binding Biological Process: ubiquinone biosynthetic process; neurogenesis; in utero embryonic development; determination of adult life span; neural tube formation; age-dependent response to oxidative stress; organelle ATP synthesis coupled electron transport |
| NCBI Summary: | The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q99807 |
| NCBI GenInfo Identifier: | 311033465 |
| NCBI Gene ID: | 10229 |
| NCBI Accession: | Q99807.3 |
| UniProt Related Accession: | Q99807 |
| Molecular Weight: | ~ 24kDa |
| NCBI Full Name: | 5-demethoxyubiquinone hydroxylase, mitochondrial |
| NCBI Synonym Full Names: | coenzyme Q7, hydroxylase |
| NCBI Official Symbol: | COQ7 |
| NCBI Official Synonym Symbols: | CAT5; CLK1; CLK-1; COQ10D8 |
| NCBI Protein Information: | 5-demethoxyubiquinone hydroxylase, mitochondrial |
| UniProt Protein Name: | Ubiquinone biosynthesis protein COQ7 homolog |
| UniProt Synonym Protein Names: | Coenzyme Q biosynthesis protein 7 homolog; Timing protein clk-1 homolog |
| Protein Family: | 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase |
| UniProt Gene Name: | COQ7 |
| UniProt Entry Name: | COQ7_HUMAN |
 | Immunohistochemistry of paraffin-embedded mouse lung using COQ7 antibody (CAB7768) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using COQ7 antibody (CAB7768) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using COQ7 antibody (CAB7768) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using COQ7 antibody (CAB7768) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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