Metabolism Antibodies 2
Anti-COQ3 Antibody (CAB7469)
- SKU:
- CAB7469
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-COQ3 Antibody |
| Antibody SKU: | CAB7469 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-369 of human COQ3 (NP_059117.3). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, NCI-H460, MCF7, Mouse liver, Mouse brain, Mouse heart, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-369 of human COQ3 (NP_059117.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PGVF NEYR TIWF KSYR TIFS CLNR IKSF RYPW ARLY STSQ TTVD SGEV KTFL ALAH KWWD EQGV YAPL HSMN DLRV PFIR DNLL KTIP NHQP GKPL LGMK ILDV GCGG GLLT EPLG RLGA SVIG IDPV DENI KTAQ CHKS FDPV LDKR IEYR VCSL EEIV EETA ETFD AVVA SEVV EHVI DLET FLQC CCQV LKPG GSLF ITTI NKTQ LSYA LGIV FSEQ IASI VPKG THTW EKFV SPET LESI LESN GLSV QTVV GMLY NPFS GYWH WSEN TSLN YAAY AVKS RVQE HPAS AEFV LKGE TEEL QANA CTNP AVHE KLKK |
| Gene ID: | 51805 |
| Uniprot: | Q9NZJ6 |
| Cellular Location: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein |
| Calculated MW: | 41kDa |
| Observed MW: | 32kDa/41kDa |
| Synonyms: | COQ3, DHHBMT, DHHBMTASE, UG0215E05, bA9819.1, coenzyme Q3 |
| Background: |
| UniProt Protein Function: | COQ3: Belongs to the methyltransferase superfamily. UbiG/COQ3 family |
| UniProt Protein Details: | Protein type:EC 2.1.1.64; Mitochondrial; Methyltransferase; EC 2.1.1.222; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; EC 2.1.1.114 Chromosomal Location of Human Ortholog: 6q16.2 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:O-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity Biological Process: glycerol metabolic process; ubiquinone biosynthetic process |
| NCBI Summary: | Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NZJ6 |
| NCBI GenInfo Identifier: | 313104241 |
| NCBI Gene ID: | 51805 |
| NCBI Accession: | Q9NZJ6.3 |
| UniProt Secondary Accession: | Q9NZJ6,Q5T061, Q6P4F0, Q8IXG6, Q96BG1, Q9H0N1, B3KPX0 |
| UniProt Related Accession: | Q9NZJ6 |
| Molecular Weight: | 41,054 Da |
| NCBI Full Name: | Ubiquinone biosynthesis O-methyltransferase, mitochondrial |
| NCBI Synonym Full Names: | coenzyme Q3, methyltransferase |
| NCBI Official Symbol: | COQ3 |
| NCBI Official Synonym Symbols: | DHHBMT; bA9819.1; DHHBMTASE; UG0215E05 |
| NCBI Protein Information: | ubiquinone biosynthesis O-methyltransferase, mitochondrial |
| UniProt Protein Name: | Ubiquinone biosynthesis O-methyltransferase, mitochondrial |
| UniProt Synonym Protein Names: | 3-demethylubiquinol 3-O-methyltransferase |
| UniProt Gene Name: | COQ3 |
| UniProt Entry Name: | COQ3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using COQ3 antibody (CAB7469) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using COQ3 antibody (CAB7469) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A549 cells using COQ3 antibody (CAB7469). Blue: DAPI for nuclear staining. |
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