Cell Biology Antibodies 10
Anti-COPS2 Antibody (CAB7037)
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- SKU:
- CAB7037
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-COPS2 Antibody |
| Antibody SKU: | CAB7037 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS2 (NP_004227.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, HeLa, A-431, Jurkat, NIH/3T3, Mouse brain, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS2 (NP_004227.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSDM EDDF MCDD EEDY DLEY SEDS NSEP NVDL ENQY YNSK ALKE DDPK AALS SFQK VLEL EGEK GEWG FKAL KQMI KINF KLTN FPEM MNRY KQLL TYIR SAVT RNYS EKSI NSIL DYIS TSKQ MDLL QEFY ETTL EALK DAKN DRLW FKTN TKLG KLYL EREE YGKL QKIL RQLH QSCQ TDDG EDDL KKGT QLLE IYAL EIQM YTAQ KNNK KLKA LYEQ SLHI KSAI PHPL IMGV IREC GGKM HLRE GEFE KAHT DFFE AFKN YDES GSPR RTTC LKYL VLAN MLMK SGIN PFDS QEAK PYKN DPEI LA |
| Gene ID: | 9318 |
| Uniprot: | P61201 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 51kDa/52kDa |
| Observed MW: | 52kDa |
| Synonyms: | COPS2, ALIEN, CSN2, SGN2, TRIP15 |
| Background: |
| UniProt Protein Function: | COPS2: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Belongs to the CSN2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q21.2 Cellular Component: cytoplasm; nucleoplasm; signalosome Molecular Function:protein binding Biological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair |
| UniProt Code: | P61201 |
| NCBI GenInfo Identifier: | 47117681 |
| NCBI Gene ID: | 9318 |
| NCBI Accession: | P61201.1 |
| UniProt Secondary Accession: | P61201,O88950, Q15647, Q6FGP4, Q9BY54, Q9R249, Q9UNI2 Q9UNQ5, |
| UniProt Related Accession: | P61201 |
| Molecular Weight: | 52,405 Da |
| NCBI Full Name: | COP9 signalosome complex subunit 2 |
| NCBI Synonym Full Names: | COP9 signalosome subunit 2 |
| NCBI Official Symbol: | COPS2 |
| NCBI Official Synonym Symbols: | CSN2; SGN2; ALIEN; TRIP15 |
| NCBI Protein Information: | COP9 signalosome complex subunit 2 |
| UniProt Protein Name: | COP9 signalosome complex subunit 2 |
| UniProt Synonym Protein Names: | Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 |
| UniProt Gene Name: | COPS2 |
| UniProt Entry Name: | CSN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using COPS2 antibody (CAB7037) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using COPS2 antibody (CAB7037) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A-549 cells using COPS2 antibody (CAB7037). |
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