Cell Biology Antibodies 2

Anti-COPG1 Antibody (CAB10551)

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SKU:
CAB10551
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-COPG1 Antibody
Antibody SKU:CAB10551
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 555-874 of human COPG1 (NP_057212.1).
Application:WB IHC
Recommended Dilution:WB 1:1000 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A375, BT-474, Mouse liver, Mouse kidney, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 555-874 of human COPG1 (NP_057212.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IPGL ERAL QQYT LEPS EKPF DLKS VPLA TAPM AEQR TEST PITA VKQP EKVA ATRQ EIFQ EQLA AVPE FRGL GPLF KSSP EPVA LTES ETEY VIRC TKHT FTNH MVFQ FDCT NTLN DQTL ENVT VQME PTEA YEVL CYVP ARSL PYNQ PGTC YTLV ALPK EDPT AVAC TFSC MMKF TVKD CDPT TGET DDEG YEDE YVLE DLEV TVAD HIQK VMKL NFEA AWDE VGDE FEKE ETFT LSTI KTLE EAVG NIVK FLGM HPCE RSDK VPDN KNTH TLLL AGVF RGGH DILV RSRL LLLD TVTM QVTA RSLE ELPV DIIL ASVG
Gene ID:22820
Uniprot:Q9Y678
Cellular Location:COPI-coated vesicle membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Peripheral membrane protein
Calculated MW:97kDa
Observed MW:105kDa
Synonyms:COPG1, COPG
Background:
UniProt Protein Function:COPG: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. Belongs to the COPG family.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: Golgi membrane; COPI vesicle coat; cytosol

Molecular Function:protein binding; structural molecule activity

Biological Process: intracellular protein transport; COPI coating of Golgi vesicle; establishment of Golgi localization; retrograde vesicle-mediated transport, Golgi to ER

UniProt Code:Q9Y678
NCBI GenInfo Identifier:12229771
NCBI Gene ID:22820
NCBI Accession:Q9Y678.1
UniProt Secondary Accession:Q9Y678,Q54AC4, A8K6M8, B3KMF6,
UniProt Related Accession:Q9Y678
Molecular Weight:874
NCBI Full Name:Coatomer subunit gamma-1
NCBI Synonym Full Names:coatomer protein complex, subunit gamma 1
NCBI Official Symbol:COPG1  
NCBI Official Synonym Symbols:COPG  
NCBI Protein Information:coatomer subunit gamma-1; gamma-COP; gamma-1-COP; gamma-coat protein; gamma-1-coat protein; coat protein gamma-cop
UniProt Protein Name:Coatomer subunit gamma-1
UniProt Synonym Protein Names:Gamma-1-coat protein; Gamma-1-COP
Protein Family:Coatomer
UniProt Gene Name:COPG1  
UniProt Entry Name:COPG1_HUMAN
Anti-COPG1 Antibody (CAB10551)Western blot analysis of extracts of various cell lines, using COPG1 antibody (CAB10551) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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