Anti-COPA Antibody (CAB19651)
- SKU:
- CAB19651
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AILJK
- Synonyms:
- HEP-COP
- Research Area:
- Cell Biology
Description
| Product Name: | COPA Rabbit mAb |
| Product Code: | CAB19651 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AILJK, HEP-COP |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human COPA |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HT-29, MCF7, Mouse lung, Rat brain |
| Immunogen: | A synthesized peptide derived from human COPA |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1314 |
| Uniprot: | P53621 |
| Calculated MW: | 138kDa |
| Observed MW: | 138KDa |
| UniProt Protein Function: | COPA: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Vesicle Chromosomal Location of Human Ortholog: 1q23.2 Cellular Component: extracellular space; membrane; cytoplasm; COPI vesicle coat; cytosol Molecular Function:hormone activity; structural molecule activity Biological Process: intracellular protein transport; COPI coating of Golgi vesicle; retrograde vesicle-mediated transport, Golgi to ER; pancreatic juice secretion |
| NCBI Summary: | In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P53621 |
| NCBI GenInfo Identifier: | 148536855 |
| NCBI Gene ID: | 1314 |
| NCBI Accession: | NP_001091868.1 |
| UniProt Secondary Accession: | P53621,Q5T201, Q8IXZ9, |
| UniProt Related Accession: | P53621 |
| Molecular Weight: | 139,324 Da |
| NCBI Full Name: | coatomer subunit alpha isoform 1 |
| NCBI Synonym Full Names: | coatomer protein complex, subunit alpha |
| NCBI Official Symbol: | COPA |
| NCBI Official Synonym Symbols: | HEP-COP |
| NCBI Protein Information: | coatomer subunit alpha; xenin; HEPCOP; proxenin; alpha-COP; alpha coat protein; alpha-coat protein |
| UniProt Protein Name: | Coatomer subunit alpha |
| UniProt Synonym Protein Names: | Alpha-coat protein; Alpha-COP; HEP-COP; HEPCOP |
| Protein Family: | Coatomer |
| UniProt Gene Name: | COPA |
| UniProt Entry Name: | COPA_HUMAN |
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