Cell Biology Antibodies 14

Anti-COPA Antibody (CAB16821)

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SKU:
CAB16821
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-COPA Antibody
Antibody SKU:CAB16821
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 550-650 of human COPA (NP_001091868.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 550-650 of human COPA (NP_001091868.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FIYT TSNH IKYA VTTG DHGI IRTL DLPI YVTR VKGN NVYC LDRE CRPR VLTI DPTE FKFK LALI NRKY DEVL HMVR NAKL VGQS IIAY LQKK GYPE VALH F
Gene ID:1314
Uniprot:P53621
Cellular Location:
Calculated MW:
Observed MW:110kDa
Anti-COPA Antibody (CAB16821)Western blot - COPA Rabbit pAb (CAB16821)
Synonyms:COPA, AILJK, HEP-COP
Background:In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
UniProt Protein Function:COPA: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular space; membrane; cytoplasm; COPI vesicle coat; cytosol

Molecular Function:hormone activity; structural molecule activity

Biological Process: intracellular protein transport; COPI coating of Golgi vesicle; retrograde vesicle-mediated transport, Golgi to ER; pancreatic juice secretion

NCBI Summary:In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P53621
NCBI GenInfo Identifier:148536855
NCBI Gene ID:1314
NCBI Accession:NP_001091868.1
UniProt Secondary Accession:P53621,Q5T201, Q8IXZ9,
UniProt Related Accession:P53621
Molecular Weight:139,324 Da
NCBI Full Name:coatomer subunit alpha isoform 1
NCBI Synonym Full Names:coatomer protein complex, subunit alpha
NCBI Official Symbol:COPA  
NCBI Official Synonym Symbols:HEP-COP  
NCBI Protein Information:coatomer subunit alpha; xenin; HEPCOP; proxenin; alpha-COP; alpha coat protein; alpha-coat protein
UniProt Protein Name:Coatomer subunit alpha
UniProt Synonym Protein Names:Alpha-coat protein; Alpha-COP; HEP-COP; HEPCOP
Protein Family:Coatomer
UniProt Gene Name:COPA  
UniProt Entry Name:COPA_HUMAN
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