Metabolism Antibodies 3

Anti-COMT Antibody (CAB4435)

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SKU:
CAB4435
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HEL-S-98n
Research Area:
Metabolism

Description

Product Name:COMT Rabbit mAb
Product Code:CAB4435
Size:20uL, 50uL, 100uL
Synonyms:HEL-S-98n
Applications:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human COMT
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:HepG2, Raji, U-87MG, Rat liver, Rat kidney
Immunogen:A synthesized peptide derived from human COMT
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1312
Uniprot:P21964
Cellular Location:Cell membrane, Cytoplasm, Extracellular side, Single-pass type II membrane protein
Calculated MW:24, 28kDa
Observed MW:25KDa/28KDa
UniProt Protein Function:COMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the mammalian catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative initiation.
UniProt Protein Details:

Protein type:Membrane protein, integral; Methyltransferase; EC 2.1.1.6; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: postsynaptic membrane; mitochondrion; membrane; axon; plasma membrane; dendritic spine; integral to membrane; cytosol

Molecular Function:protein binding; magnesium ion binding; O-methyltransferase activity; catechol O-methyltransferase activity

Biological Process: response to drug; methylation; estrogen metabolic process; cellular response to phosphate starvation; neurotransmitter catabolic process; dopamine catabolic process; negative regulation of smooth muscle cell proliferation; short-term memory; response to pain; response to lipopolysaccharide; female pregnancy; learning; reproductive process in a multicellular organism; response to organic cyclic substance; positive regulation of homocysteine metabolic process; negative regulation of dopamine metabolic process; synaptic transmission; xenobiotic metabolic process; regulation of sensory perception of pain; developmental process; neurotransmitter biosynthetic process

Disease: Schizophrenia; Panic Disorder 1

NCBI Summary:Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
UniProt Code:P21964
NCBI GenInfo Identifier:116907
NCBI Gene ID:1312
NCBI Accession:P21964.2
UniProt Secondary Accession:P21964,Q6IB07, Q6ICE6, Q9BWC7, A8MPV9,
UniProt Related Accession:P21964
Molecular Weight:271
NCBI Full Name:Catechol O-methyltransferase
NCBI Synonym Full Names:catechol-O-methyltransferase
NCBI Official Symbol:COMT  
NCBI Official Synonym Symbols:HEL-S-98n  
NCBI Protein Information:catechol O-methyltransferase; epididymis secretory sperm binding protein Li 98n
UniProt Protein Name:Catechol O-methyltransferase
Protein Family:Catechol O-methyltransferase
UniProt Gene Name:COMT  
UniProt Entry Name:COMT_HUMAN
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