Cell Biology Antibodies 11
Anti-COMMD1 Antibody (CAB7149)
- SKU:
- CAB7149
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-COMMD1 Antibody |
| Antibody SKU: | CAB7149 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human COMMD1 (NP_689729.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human COMMD1 (NP_689729.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAG ELEG GKPL SGLL NALA QDTF HGYP GITE ELLR SQLY PEVP PEEF RPFL AKMR GILK SIAS ADMD FNQL EAFL TAQT KKQG GITS DQAA VISK FWKS HKTK IRES LMNQ SRWN SGLR GLSW RVDG KSQS RHSA QIHT PVAI IELE LGKY GQES EFLC LEFD EVKV NQIL KTLS EVEE SIST LISQ PN |
| Gene ID: | 150684 |
| Uniprot: | Q8N668 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Early endosome, Endosome membrane, Nucleus, Recycling endosome |
| Calculated MW: | 17kDa/21kDa |
| Observed MW: | Refer to figures |
| Synonyms: | COMMD1, C2orf5, MURR1 |
| Background: |
| UniProt Protein Function: | COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 2p15 Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; cytoplasmic membrane-bound vesicle; early endosome; endosome membrane; nucleoplasm; nucleus; recycling endosome Molecular Function:copper ion binding; identical protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity Biological Process: copper ion homeostasis; Golgi to plasma membrane transport; inhibition of NF-kappaB transcription factor; plasma membrane to endosome transport; positive regulation of protein ubiquitination; protein transport; regulation of proteasomal ubiquitin-dependent protein catabolic process; transcription, DNA-dependent |
| NCBI Summary: | COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009] |
| UniProt Code: | Q8N668 |
| NCBI GenInfo Identifier: | 51316026 |
| NCBI Gene ID: | 150684 |
| NCBI Accession: | Q8N668.1 |
| UniProt Secondary Accession: | Q8N668,Q96GS0, B4DFQ4, |
| UniProt Related Accession: | Q8N668 |
| Molecular Weight: | 17,665 Da |
| NCBI Full Name: | COMM domain-containing protein 1 |
| NCBI Synonym Full Names: | copper metabolism domain containing 1 |
| NCBI Official Symbol: | COMMD1 |
| NCBI Official Synonym Symbols: | MURR1; C2orf5 |
| NCBI Protein Information: | COMM domain-containing protein 1 |
| UniProt Protein Name: | COMM domain-containing protein 1 |
| UniProt Synonym Protein Names: | Protein Murr1 |
| Protein Family: | COMM domain-containing protein |
| UniProt Gene Name: | COMMD1 |
| UniProt Entry Name: | COMD1_HUMAN |
 | Immunofluorescence analysis of L929 cells using COMMD1 antibody (CAB7149) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U2OS cells using COMMD1 antibody (CAB7149) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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