Cell Biology Antibodies 17
Anti-Collagen XVII Antibody (CAB4808)
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- SKU:
- CAB4808
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Collagen XVII Antibody |
| Antibody SKU: | CAB4808 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Collagen XVII |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | A-431 |
| Immunogen: | A synthesized peptide derived from human Collagen XVII |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1308 |
| Uniprot: | Q9UMD9 |
| Cellular Location: | |
| Calculated MW: | 130, 180kDa |
| Observed MW: | 180KDa |
| Synonyms: | BA16H23.2, BP180, BPA-2, BPAG2, ERED, LAD-1 |
| Background: | This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | COL17A1: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Defects in COL17A1 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 10q24.3 Cellular Component: collagen; hemidesmosome; endoplasmic reticulum lumen; integral to plasma membrane; plasma membrane; extracellular region; basement membrane; intercellular junction Molecular Function:protein binding Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; epidermis development; hemidesmosome assembly; cell-matrix adhesion Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type |
| NCBI Summary: | This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UMD9 |
| NCBI GenInfo Identifier: | 119829187 |
| NCBI Gene ID: | 1308 |
| NCBI Accession: | NP_000485.3 |
| UniProt Secondary Accession: | Q9UMD9,Q02802, Q5JV36, Q99018, Q9NQK9, Q9UC14, |
| UniProt Related Accession: | Q9UMD9 |
| Molecular Weight: | 150,419 Da |
| NCBI Full Name: | collagen alpha-1(XVII) chain |
| NCBI Synonym Full Names: | collagen, type XVII, alpha 1 |
| NCBI Official Symbol: | COL17A1 |
| NCBI Official Synonym Symbols: | BP180; BPA-2; BPAG2; LAD-1; BA16H23.2 |
| NCBI Protein Information: | collagen alpha-1(XVII) chain; collagen alpha-1(XVII) chain; alpha 1 type XVII collagen; type XVII collagen alpha-1; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type X |
| UniProt Protein Name: | Collagen alpha-1(XVII) chain |
| UniProt Synonym Protein Names: | 180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2Cleaved into the following 2 chains:120 kDa linear IgA disease antigen; Alternative name(s):; 120 kDa linear IgA dermatosis antigen; Linear IgA disease antigen 1; LAD-197 kDa linear IgA disease antigen; Alternative name(s):; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa LAD antigen; 97-LAD; Linear IgA bullous disease antigen of 97 kDa |
| UniProt Gene Name: | COL17A1 |
| UniProt Entry Name: | COHA1_HUMAN |
 | Western blot - Collagen XVII Rabbit mAb (CAB4808) |
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