Immunology Antibodies 2

Anti-COLEC11 Antibody (CAB4955)

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SKU:
CAB4955
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
COLEC11
Synonyms:
3MC2
Synonyms:
CL-K1-I
Synonyms:
CL-K1-II
Synonyms:
CL-K1-IIa
Synonyms:
CL-K1-IIb
Synonyms:
CLK1
Research Area:
Immunology

Description

Product Name:COLEC11 Rabbit pAb
Product Code:CAB4955
Size:20uL, 50uL, 100uL
Synonyms:COLEC11, 3MC2, CL-K1-I, CL-K1-II, CL-K1-IIa, CL-K1-IIb, CLK1
Applications:WB, IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-271 of human COLEC11 (NP_076932.1).
Applications:WB, IHC
Recommended Dilutions:WB 1:200 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Rat
Positive Samples:MCF7, THP-1
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-271 of human COLEC11 (NP_076932.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QPAG DDAC SVQI LVPG LKGD AGEK GDKG APGR PGRV GPTG EKGD MGDK GQKG SVGR HGKI GPIG SKGE KGDS GDIG PPGP NGEP GLPC ECSQ LRKA IGEM DNQV SQLT SELK FIKN AVAG VRET ESKI YLLV KEEK RYAD AQLS CQGR GGTL SMPK DEAA NGLM AAYL AQAG LARV FIGI NDLE KEGA FVYS DHSP MRTF NKWR SGEP NNAY DEED CVEM VASG GWND VACH TTMY FMCE FDKE NM
Gene ID:78989
Uniprot:Q9BWP8
Cellular Location:Secreted
Calculated MW:21kDa/23kDa/24kDa/26kDa/28kDa/29kDa/30kDa
Observed MW:35kDa
UniProt Protein Function:Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481).
NCBI Summary:This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q9BWP8
NCBI GenInfo Identifier:13128972
NCBI Gene ID:78989
NCBI Accession:NP_076932
UniProt Related Accession:Q9BWP8
Molecular Weight:28.665
NCBI Full Name:collectin-11 isoform a
NCBI Synonym Full Names:collectin subfamily member 11
NCBI Official Symbol:COLEC11  
NCBI Official Synonym Symbols:3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb  
NCBI Protein Information:collectin-11
UniProt Protein Name:Collectin-11
UniProt Synonym Protein Names:Collectin kidney protein 1; CL-K1
Protein Family:Collectin
UniProt Gene Name:COLEC11  
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