Anti-COL7A1 Antibody (CAB20187)

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SKU:
CAB20187
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EBD1
Synonyms:
EBDCT
Synonyms:
EBR1
Synonyms:
NDNC8

Description

Product Name:COL7A1 Rabbit pAb
Product Code:CAB20187
Size:50uL, 100uL
Synonyms:EBD1, EBDCT, EBR1, NDNC8
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human COL7A1.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:Recombinant protein of human COL7A1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1294
Uniprot:Q02388
Observed MW:Refer to figures
UniProt Protein Function:COL7A1: the alpha chain of type VII collagen, an extra-cellular basement membrane protein restricted to the zone beneath stratified squamous epithelia. Type VII collagen fibrils are composed of three identical alpha collagen chains. Forms anchoring fibrils, which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Dystrophic epidermolysis bullosa can result from defects in this protein or an autoimmune response made to type VII collagen. Homotrimer. Interacts with MIA3, facilitating its loading into transport carriers and subsequent secretion. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Extracellular matrix; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: basement membrane; collagen type VII; endoplasmic reticulum lumen; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; extracellular matrix; extracellular region; extracellular space; Golgi membrane

Molecular Function:identical protein binding; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: cell adhesion; cellular protein metabolic process; collagen catabolic process; COPII coating of Golgi vesicle; epidermis development; ER to Golgi vesicle-mediated transport; extracellular matrix disassembly; extracellular matrix organization and biogenesis; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine

Disease: Epidermolysis Bullosa Dystrophica, Autosomal Dominant; Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Epidermolysis Bullosa Dystrophica, Pretibial; Epidermolysis Bullosa Pruriginosa; Epidermolysis Bullosa With Congenital Localized Absence Of Skin And Deformity Of Nails; Nail Disorder, Nonsyndromic Congenital, 8; Transient Bullous Dermolysis Of The Newborn

NCBI Summary:This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]
UniProt Code:Q02388
NCBI GenInfo Identifier:1345650
NCBI Gene ID:1294
NCBI Accession:Q02388.2
UniProt Secondary Accession:Q02388,Q14054, Q16507,
UniProt Related Accession:Q02388
Molecular Weight:292,267 Da
NCBI Full Name:Collagen alpha-1(VII) chain
NCBI Synonym Full Names:collagen type VII alpha 1
NCBI Official Symbol:COL7A1  
NCBI Official Synonym Symbols:EBD1; EBR1; EBDCT; NDNC8  
NCBI Protein Information:collagen alpha-1(VII) chain
UniProt Protein Name:Collagen alpha-1(VII) chain
UniProt Synonym Protein Names:Long-chain collagen; LC collagen
UniProt Gene Name:COL7A1  
UniProt Entry Name:CO7A1_HUMAN
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