Cell Biology Antibodies 6
Anti-COL2A1 Antibody (CAB1560)
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- SKU:
- CAB1560
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-COL2A1 Antibody |
| Antibody SKU: | CAB1560 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 873-1072 of human COL2A1 (NP_149162.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 873-1072 of human COL2A1 (NP_149162.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GEPG LQGP AGPP GEKG EPGD DGPS GAEG PPGP QGLA GQRG IVGL PGQR GERG FPGL PGPS GEPG KQGA PGAS GDRG PPGP VGPP GLTG PAGE PGRE GSPG ADGP PGRD GAAG VKGD RGET GAVG APGA PGPP GSPG PAGP TGKQ GDRG EAGA QGPM GPSG PAGA RGIQ GPQG PRGD KGEA GEPG ERGL KGHR GFTG LQGL |
| Gene ID: | 1280 |
| Uniprot: | P02458 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 29kDa/134kDa/141kDa |
| Observed MW: | 141kDa |
| Synonyms: | COL2A1, ANFH, AOM, COL11A3, SEDC, STL1 | ||
| Background: | This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. |
| UniProt Protein Function: | Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. |
| NCBI Summary: | This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02458 |
| NCBI GenInfo Identifier: | 124056489 |
| NCBI Gene ID: | 1280 |
| NCBI Accession: | P02458.3 |
| UniProt Secondary Accession: | P02458,Q12985, Q14009, Q14044, Q14045, Q14046, Q14047 Q14056, Q14058, Q16672, Q1JQ82, A6NGA0, |
| UniProt Related Accession: | P02458 |
| Molecular Weight: | 134,389 Da |
| NCBI Full Name: | Collagen alpha-1(II) chain |
| NCBI Synonym Full Names: | collagen type II alpha 1 chain |
| NCBI Official Symbol: | COL2A1 |
| NCBI Official Synonym Symbols: | AOM; ANFH; SEDC; STL1; COL11A3 |
| NCBI Protein Information: | collagen alpha-1(II) chain |
| UniProt Protein Name: | Collagen alpha-1(II) chain |
| UniProt Synonym Protein Names: | Alpha-1 type II collagenCurated |
| UniProt Gene Name: | COL2A1 |
 | Western blot analysis of extracts of mouse liver, using COL2A1 antibody (CAB1560) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded Human breast cancer using COL2A1 Rabbit pAb (CAB1560) at dilution of 1:100 (40x lens). |
| Vora et al. | A study of COL2A1 Expression in triple-negative breast cancer patients | Bioinformatics in Clinical Cancer Research 2023 | View Citation |
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