Cell Biology Antibodies 7
Anti-COL18A1 Antibody (CAB1722)
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- SKU:
- CAB1722
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-COL18A1 Antibody |
| Antibody SKU: | CAB1722 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human COL18A1 (NP_085059.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human COL18A1 (NP_085059.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PGLP GNQG PPGP KGAK GEVG PPGP PGQF PFDF LQLE AEMK GEKG DRGD AGQK GERG EPGG GGFF GSSL PGPP GPPG PRGY PGIP GPKG ESIR GQPG PPGP Q |
| Gene ID: | 80781 |
| Uniprot: | P39060 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 135kDa/154kDa/178kDa |
| Observed MW: | 240kDa |
| Synonyms: | COL18A1, KNO, KNO1, KS |
| Background: | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | COL18A1: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1). An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele. Belongs to the multiplexin collagen family. 3 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis; negative regulation of cell proliferation; organ morphogenesis; visual perception Disease: Knobloch Syndrome 1 |
| NCBI Summary: | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P39060 |
| NCBI GenInfo Identifier: | 215274264 |
| NCBI Gene ID: | 80781 |
| NCBI Accession: | P39060.5 |
| UniProt Secondary Accession: | P39060,Q58EX6, Q6RZ39, Q6RZ40, Q6RZ41, Q8N4S4, Q8WXI5 Q96T70, Q9UK38, Q9Y6Q7, Q9Y6Q8, A8MVI4, |
| UniProt Related Accession: | P39060 |
| Molecular Weight: | 135,761 Da |
| NCBI Full Name: | Collagen alpha-1(XVIII) chain |
| NCBI Synonym Full Names: | collagen type XVIII alpha 1 chain |
| NCBI Official Symbol: | COL18A1 |
| NCBI Official Synonym Symbols: | KS; KNO; KNO1 |
| NCBI Protein Information: | collagen alpha-1(XVIII) chain |
| UniProt Protein Name: | Collagen alpha-1(XVIII) chain |
| Protein Family: | Collagen |
| UniProt Gene Name: | COL18A1 |
| UniProt Entry Name: | COIA1_HUMAN |
 | Western blot analysis of extracts of mouse lung, using COL18A1 antibody (CAB1722) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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