Antibody Name:	Anti-COL12A1 Antibody
Antibody SKU:	CAB17462
Antibody Size:	20uL, 50 uL
Application:	IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-270 of human COL12A1 (NP_004361.3).

Application:	IF
Recommended Dilution:	IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 24-270 of human COL12A1 (NP_004361.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	EVDP PSDL NFKI IDEN TVHM SWAK PVDP IVGY RITV DPTT DGPT KEFT LSAS TTET LLSE LVPE TEYV VTIT SYDE VEES VPVI GQLT IQTG SSTK PVEK KPGK TEIQ KCSV SAWT DLVF LVDG SWSV GRNN FKYI LDFI AALV SAFD IGEE KTRV GVVQ YSSD TRTE FNLN QYYQ RDEL LAAI KKIP YKGG NTMT GDAI DYLV KNTF TESA GARV GFPK VAII ITDG KSQD EVEI PARE LRNV GVE
Gene ID:	1303
Uniprot:	Q99715
Cellular Location:
Calculated MW:
Observed MW:	Refer to figures

Synonyms:

BA209D8.1, BTHLM2, COL12A1L, DJ234P15.1, UCMD2, COL12A1

Background:

This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

UniProt Protein Function:	COL12A1: Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Extracellular matrix; Secreted Chromosomal Location of Human Ortholog: 6q12-q13 Cellular Component: collagen type XII; extracellular matrix; extracellular space; endoplasmic reticulum lumen; extracellular region; vesicle Molecular Function:extracellular matrix structural constituent conferring tensile strength Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; collagen fibril organization; cell adhesion; skeletal development Disease: Ullrich Congenital Muscular Dystrophy 2; Bethlem Myopathy 2
NCBI Summary:	This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:	Q99715
NCBI GenInfo Identifier:	93141047
NCBI Gene ID:	1303
NCBI Accession:	NP_004361.3
UniProt Related Accession:	Q99715
Molecular Weight:	Predicted Molecular Mass: 21.5kDaAccurate Molecular Mass: 29kDa
NCBI Full Name:	collagen alpha-1(XII) chain long isoform
NCBI Synonym Full Names:	collagen type XII alpha 1 chain
NCBI Official Symbol:	COL12A1
NCBI Official Synonym Symbols:	UCMD2; BTHLM2; EDSMYP; COL12A1L; BA209D8.1; DJ234P15.1
NCBI Protein Information:	collagen alpha-1(XII) chain
UniProt Protein Name:	Collagen alpha-1(XII) chain
Protein Family:	Lantibiotic salivaricin
UniProt Gene Name:	COL12A1
UniProt Entry Name:	COCA1_HUMAN