Cell Biology Antibodies 17

Anti-Coilin Antibody (CAB3483)

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SKU:
CAB3483
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Coilin Antibody
Antibody SKU:CAB3483
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Coilin
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, Mouse lung
Immunogen:A synthesized peptide derived from human Coilin
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8161
Uniprot:P38432
Cellular Location:
Calculated MW:80kDa
Observed MW:80KDa
Synonyms:CLN80, p80-coilin
Background:The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
UniProt Protein Function:coilin: an ubiquitous protein found in nuclear coiled bodies (CBS), nuclear suborganelles involved in the post-transcriptional modification of snRNPs and small nucleolar RNAs. snRNPs undergo 2'-O-methylation and pseudouridylation in CBS. Differential methylation and phosphorylation of coilin likely influences localization among nuclear bodies and the composition and assembly of CBS. Located in the interchromatin space between the nucleolus and the nucleus.
UniProt Protein Details:

Protein type:Oxidoreductase

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: nucleoplasm; Cajal body; membrane; cytoplasm; nucleolus; nucleus

Molecular Function:protein C-terminus binding; identical protein binding; protein binding

NCBI Summary:The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
UniProt Code:P38432
NCBI GenInfo Identifier:585632
NCBI Gene ID:8161
NCBI Accession:P38432.1
UniProt Secondary Accession:P38432,B2R931,
UniProt Related Accession:P38432
Molecular Weight:576
NCBI Full Name:Coilin
NCBI Synonym Full Names:coilin
NCBI Official Symbol:COIL  
NCBI Official Synonym Symbols:CLN80; p80-coilin  
NCBI Protein Information:coilin; p80; coilin p80
UniProt Protein Name:Coilin
UniProt Synonym Protein Names:p80-coilin
Protein Family:Coilin
UniProt Gene Name:COIL  
UniProt Entry Name:COIL_HUMAN
Anti-Coilin Antibody (CAB3483)Western blot - Coilin Rabbit mAb (CAB3483)
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