Cell Biology Antibodies 4

Anti-COG8 Antibody (CAB14361)

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SKU:
CAB14361
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-COG8 Antibody
Antibody SKU:CAB14361
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 394-612 of human COG8 (NP_115758.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Jurkat, A-431
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 394-612 of human COG8 (NP_115758.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNSY MLIS APAI LGTS NMPA AVPA TQPG TLQP PMVL LDFP PLAC FLNN ILVA FNDL RLCC PVAL AQDV TGAL EDAL AKVT KIIL AFHR AEEA AFSS GEQE LFVQ FCTV FLED LVPY LNRC LQVL FPPA QIAQ TLGI PPTQ LSKY GNLG HVNI GAIQ EPLA FILP KRET LFTL DDQA LGPE LTAP APEP PAEE PRLE PAGP ACPE GGRA ETQA EPPS VGP
Gene ID:84342
Uniprot:Q96MW5
Cellular Location:Golgi apparatus membrane, Peripheral membrane protein
Calculated MW:68kDa
Observed MW:68kDa
Synonyms:COG8, CDG2H, DOR1
Background:This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance.
UniProt Protein Function:COG8: Required for normal Golgi function. Defects in COG8 are the cause of congenital disorder of glycosylation type 2H (CDG2H). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the COG8 family.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: Golgi membrane; membrane; Golgi transport complex

Biological Process: protein transport

Disease: Congenital Disorder Of Glycosylation, Type Iih

NCBI Summary:This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]
UniProt Code:Q96MW5
NCBI GenInfo Identifier:186928841
NCBI Gene ID:84342
NCBI Accession:NP_115758.3
UniProt Secondary Accession:Q96MW5,Q0VAK2, Q8WVV6, Q9H6F8,
UniProt Related Accession:Q96MW5
Molecular Weight:68,424 Da
NCBI Full Name:conserved oligomeric Golgi complex subunit 8
NCBI Synonym Full Names:component of oligomeric golgi complex 8
NCBI Official Symbol:COG8  
NCBI Official Synonym Symbols:DOR1; CDG2H  
NCBI Protein Information:conserved oligomeric Golgi complex subunit 8; dependent on RIC1; COG complex subunit 8; conserved oligomeric golgi complex component 8
UniProt Protein Name:Conserved oligomeric Golgi complex subunit 8
UniProt Synonym Protein Names:Component of oligomeric Golgi complex 8
Protein Family:Conserved oligomeric Golgi complex
UniProt Gene Name:COG8  
UniProt Entry Name:COG8_HUMAN
Anti-COG8 Antibody (CAB14361)Western blot analysis of extracts of various cell lines, using COG8 antibody (CAB14361) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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