Anti-Cofilin Antibody (CAB2658)

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SKU:
CAB2658
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CFL1
Synonyms:
CFL
Synonyms:
HEL-S-15
Synonyms:
cofilin
Synonyms:
cofilin-1
Research Area:
Cell Biology

Description

Product Name:Cofilin Rabbit mAb
Product Code:CAB2658
Size:20uL, 50uL, 100uL
Synonyms:CFL1, CFL, HEL-S-15, cofilin, cofilin-1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cofilin.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, MCF7, NIH/3T3, C6, Mouse lung, Mouse thymus, Rat brain
Immunogen:A synthesized peptide derived from human Cofilin.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1072
Uniprot:P23528
Cellular Location:Cell projection, Cytoplasm, Cytoplasmic side, Nucleus matrix, Peripheral membrane protein, cytoskeleton, lamellipodium membrane, ruffle membrane
Calculated MW:19kDa
Observed MW:18KDa
UniProt Protein Function:Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cortical actin cytoskeleton; cytoplasm; extracellular space; focal adhesion; intercellular junction; membrane; nuclear matrix; nucleus; vesicle

Molecular Function:actin binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; actin filament depolymerization; axon guidance; blood coagulation; cytokinesis after mitosis; cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; establishment of cell polarity; innate immune response; negative regulation of apoptosis; neural crest cell migration; neural fold formation; platelet activation; platelet degranulation; positive regulation of actin filament depolymerization; protein amino acid phosphorylation; regulation of cell morphogenesis; response to amino acid stimulus; response to virus; Rho protein signal transduction

NCBI Summary:The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
UniProt Code:P23528
NCBI GenInfo Identifier:116848
NCBI Gene ID:1072
NCBI Accession:P23528.3
UniProt Secondary Accession:P23528,Q53Y87, Q9UCA2, B3KUQ1,
UniProt Related Accession:P23528
Molecular Weight:18,502 Da
NCBI Full Name:Cofilin-1
NCBI Synonym Full Names:cofilin 1
NCBI Official Symbol:CFL1  
NCBI Official Synonym Symbols:CFL; cofilin; HEL-S-15  
NCBI Protein Information:cofilin-1
UniProt Protein Name:Cofilin-1
UniProt Synonym Protein Names:18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform
Protein Family:Cofilin
UniProt Gene Name:CFL1  
UniProt Entry Name:COF1_HUMAN
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