Cell Biology Antibodies 11
Anti-Cofilin-2 Antibody (CAB8009)
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- SKU:
- CAB8009
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | CFL2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8009 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CFL2 (NP_068733.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, HeLa, Raji, NCI-H460, Mouse heart, Mouse skeletal muscle, Mouse kidney, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CFL2 (NP_068733.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASG VTVN DEVI KVFN DMKV RKSS TQEE IKKR KKAV LFCL SDDK RQII VEEA KQIL VGDI GDTV EDPY TSFV KLLP LNDC RYAL YDAT YETK ESKK EDLV FIFW APES APLK SKMI YASS KDAI KKKF TGIK HEWQ VNGL DDIK DRST LGEK LGGN VVVS LEGK PL |
| Gene ID: | 1073 |
| Uniprot: | Q9Y281 |
| Cellular Location: | Cytoplasm, Nucleus matrix, cytoskeleton |
| Calculated MW: | 16kDa/18kDa |
| Observed MW: | 18kDa |
| Synonyms: | CFL2, NEM7, cofilin-2 |
| Background: | This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Cofilin-2: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 14q12 Cellular Component: extracellular space; I band Molecular Function:protein binding Biological Process: positive regulation of actin filament depolymerization Disease: Nemaline Myopathy 7 |
| NCBI Summary: | This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] |
| UniProt Code: | Q9Y281 |
| NCBI GenInfo Identifier: | 6831517 |
| NCBI Gene ID: | 1073 |
| NCBI Accession: | Q9Y281.1 |
| UniProt Secondary Accession: | Q9Y281,G3V5P4, |
| UniProt Related Accession: | Q9Y281 |
| Molecular Weight: | Da |
| NCBI Full Name: | Cofilin-2 |
| NCBI Synonym Full Names: | cofilin 2 |
| NCBI Official Symbol: | CFL2 |
| NCBI Official Synonym Symbols: | NEM7 |
| NCBI Protein Information: | cofilin-2 |
| UniProt Protein Name: | Cofilin-2 |
| UniProt Synonym Protein Names: | Cofilin, muscle isoform |
| Protein Family: | Cofilin |
| UniProt Gene Name: | CFL2 |
| UniProt Entry Name: | COF2_HUMAN |
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