Anti-CoA synthase (COASY? Antibody (CAB0928)
- SKU:
- CAB0928
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- COASY
- Synonyms:
- DPCK
- Synonyms:
- NBIA6
- Synonyms:
- NBP
- Synonyms:
- PPAT
- Synonyms:
- UKR1
- Synonyms:
- pOV-2
- Synonyms:
- Coenzyme A synthase
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | CoA synthase (COASY? Rabbit mAb |
| Product Code: | CAB0928 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | COASY, DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2, Coenzyme A synthase |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CoA synthase (COASY?. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29, 293T |
| Immunogen: | A synthesized peptide derived from human CoA synthase (COASY?. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 80347 |
| Uniprot: | Q13057 |
| Cellular Location: | Cytoplasm, Mitochondrion matrix |
| Calculated MW: | 62kDa |
| Observed MW: | 62KDa |
| UniProt Protein Function: | PPAT: bifunctional cytoplasmic enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. |
| UniProt Protein Details: | Protein type:Kinase, other; EC 2.7.7.3; Transferase; EC 2.7.1.24; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis Chromosomal Location of Human Ortholog: 17q12-q21 Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrial matrix; cytoplasm Molecular Function:protein binding; dephospho-CoA kinase activity; pantetheine-phosphate adenylyltransferase activity; ATP binding Biological Process: coenzyme A biosynthetic process; coenzyme biosynthetic process; vitamin metabolic process; pantothenate metabolic process; phosphorylation; water-soluble vitamin metabolic process Disease: Neurodegeneration With Brain Iron Accumulation 6 |
| NCBI Summary: | Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q13057 |
| NCBI GenInfo Identifier: | 32363505 |
| NCBI Gene ID: | 80347 |
| NCBI Accession: | Q13057.4 |
| UniProt Related Accession: | Q13057 |
| Molecular Weight: | |
| NCBI Full Name: | Bifunctional coenzyme A synthase |
| NCBI Synonym Full Names: | Coenzyme A synthase |
| NCBI Official Symbol: | COASY |
| NCBI Official Synonym Symbols: | NBP; DPCK; PPAT; UKR1; NBIA6; PCH12; pOV-2 |
| NCBI Protein Information: | bifunctional coenzyme A synthase |
| UniProt Protein Name: | Bifunctional coenzyme A synthase |
| UniProt Synonym Protein Names: | NBP; POV-2Including the following 2 domains:Phosphopantetheine adenylyltransferase (EC:2.7.7.3)Alternative name(s):Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT |
| Protein Family: | Bifunctional coenzyme A synthase |
| UniProt Gene Name: | COASY |
| UniProt Entry Name: | COASY_HUMAN |
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