Cell Biology Antibodies 1
Anti-CNTN4 Antibody (CAB10339)
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- SKU:
- CAB10339
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CNTN4 Antibody |
| Antibody SKU: | CAB10339 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 448-697 of human CNTN4 (NP_001193885.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, HeLa, HT-1080 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 448-697 of human CNTN4 (NP_001193885.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VGVF NNKG EGPF SPTT VVYS AEEE PTKP PASI FARS LSAT DIEV FWAS PLEK NRGR IQGY EVKY WRHE DKEE NARK IRTV GNQT STKI TNLK GSVL YHLA VKAY NSAG TGPS SATV NVTT RKPP PSQP PGNI IWNS SDSK IILN WDQV KALD NESE VKGY KVLY RWNR QSST SVIE TNKT SVEL SLPF DEDY IIEI KPFS DGGD GSSS EQIR IPKI SNAY ARGS GAST SNAC TLSA ISTI MISL TARS SL |
| Gene ID: | 152330 |
| Uniprot: | Q8IWV2 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor, Secreted |
| Calculated MW: | 31kDa/76kDa/113kDa |
| Observed MW: | 113kDa |
| Synonyms: | CNTN4, AXCAM, BIG-2 |
| Background: | This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CNTN4: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis. A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features. Belongs to the immunoglobulin superfamily. Contactin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 3p26.3-p26.2 Cellular Component: extracellular region; plasma membrane Biological Process: axon guidance; axonal fasciculation; axonogenesis; brain development; C-terminal protein lipidation; negative regulation of neuron differentiation; nervous system development; neurite development; neuron adhesion; regulation of synaptic plasticity |
| NCBI Summary: | This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011] |
| UniProt Code: | Q8IWV2 |
| NCBI GenInfo Identifier: | 55976529 |
| NCBI Gene ID: | 152330 |
| NCBI Accession: | Q8IWV2.1 |
| UniProt Secondary Accession: | Q8IWV2,Q8IX14, Q8TC35, B2RAX3, |
| UniProt Related Accession: | Q8IWV2 |
| Molecular Weight: | 113kDa |
| NCBI Full Name: | Contactin-4 |
| NCBI Synonym Full Names: | contactin 4 |
| NCBI Official Symbol: | CNTN4 |
| NCBI Official Synonym Symbols: | AXCAM; BIG-2 |
| NCBI Protein Information: | contactin-4 |
| UniProt Protein Name: | Contactin-4 |
| UniProt Synonym Protein Names: | Brain-derived immunoglobulin superfamily protein 2; BIG-2 |
| Protein Family: | Contactin |
| UniProt Gene Name: | CNTN4 |
 | Western blot analysis of extracts of various cell lines, using CNTN4 antibody (CAB10339) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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