Cell Biology Antibodies 11
Anti-CNTN2 Antibody (CAB7738)
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- SKU:
- CAB7738
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CNTN2 Antibody |
| Antibody SKU: | CAB7738 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 785-1012 of human CNTN2 (NP_005067.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse spinal cord, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 785-1012 of human CNTN2 (NP_005067.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EVKI RSYN RRGD GPES LTAL VYSA EEEP RVAP TKVW AKGV SSSE MNVT WEPV QQDM NGIL LGYE IRYW KAGD KEAA ADRV RTAG LDTS ARVS GLHP NTKY HVTV RAYN RAGT GPAS PSAN ATTM KPPP RRPP GNIS WTFS SSSL SIKW DPVV PFRN ESAV TGYK MLYQ NDLH LTPT LHLT GKNW IEIP VPED IGHA LVQI RTTG PGGD GIPA EVHI VRNG GTSM MVEN |
| Gene ID: | 6900 |
| Uniprot: | Q02246 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 113kDa |
| Observed MW: | 130kDa |
| Synonyms: | CNTN2, AXT, FAME5, TAG-1, TAX, TAX1 |
| Background: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. |
| UniProt Protein Function: | CNTN2: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. Belongs to the immunoglobulin superfamily. Contactin family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Cell adhesion Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: voltage-gated potassium channel complex; cell surface; cell soma; integral to plasma membrane; plasma membrane; synapse; myelin sheath Molecular Function:identical protein binding; protein self-association; carbohydrate binding; glycoprotein binding Biological Process: axon guidance; cerebral cortex GABAergic interneuron migration; myelination in the central nervous system; positive regulation of adenosine receptor signaling pathway; axonal fasciculation; regulation of astrocyte differentiation; microtubule cytoskeleton organization and biogenesis; learning; adult walking behavior; negative regulation of neuron differentiation; receptor internalization; clustering of voltage-gated potassium channels; regulation of axon diameter; cell adhesion; regulation of neuronal synaptic plasticity Disease: Epilepsy, Familial Adult Myoclonic, 5 |
| NCBI Summary: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02246 |
| NCBI GenInfo Identifier: | 4827022 |
| NCBI Gene ID: | 6900 |
| NCBI Accession: | NP_005067.1 |
| UniProt Secondary Accession: | Q02246,P78432, Q5T054, |
| UniProt Related Accession: | Q02246 |
| Molecular Weight: | |
| NCBI Full Name: | contactin-2 |
| NCBI Synonym Full Names: | contactin 2 (axonal) |
| NCBI Official Symbol: | CNTN2 |
| NCBI Official Synonym Symbols: | AXT; TAX; TAX1; FAME5; TAG-1 |
| NCBI Protein Information: | contactin-2; axonal glycoprotein TAG-1; axonin-1 cell adhesion molecule; transient axonal glycoprotein 1; contactin 2 (transiently expressed); transiently-expressed axonal glycoprotein |
| UniProt Protein Name: | Contactin-2 |
| UniProt Synonym Protein Names: | Axonal glycoprotein TAG-1; Axonin-1; Transient axonal glycoprotein 1; TAX-1 |
| Protein Family: | Contactin |
| UniProt Gene Name: | CNTN2 |
| UniProt Entry Name: | CNTN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CNTN2 antibody (CAB7738) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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