Name: Anti-CNTFR Antibody (CAB2700)
Brand: Cell Biology Antibodies 8
SKU: CAB2700
Availability: OutOfStock

Antibody Name:	Anti-CNTFR Antibody
Antibody SKU:	CAB2700
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 190-340 of human CNTFR (NP_001833.1).

Application:	WB
Recommended Dilution:	WB 1:400 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-87MG, HeLa, Mouse brain, Mouse heart, Rat testis

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 190-340 of human CNTFR (NP_001833.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NATA ITFD EFTI VKPD PPEN VVAR PVPS NPRR LEVT WQTP STWP DPES FPLK FFLR YRPL ILDQ WQHV ELSD GTAH TITD AYAG KEYI IQVA AKDN EIGT WSDW SVAA HATP WTEE PRHL TTEA QAAE TTTS TTSS LAPP PTTK ICDP GEL
Gene ID:	1271
Uniprot:	P26992
Cellular Location:	Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:	40kDa
Observed MW:	41kDa

Synonyms:

CNTFR

Background:

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.

UniProt Protein Function:	CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily.
UniProt Protein Details:	Protein type:Membrane protein, GPI anchor; Receptor, misc. Chromosomal Location of Human Ortholog: 9p13 Cellular Component: extrinsic to membrane Molecular Function:cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation
NCBI Summary:	This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
UniProt Code:	P26992
NCBI GenInfo Identifier:	1352099
NCBI Gene ID:	1271
NCBI Accession:	P26992.2
UniProt Related Accession:	P26992
Molecular Weight:	40kDa
NCBI Full Name:	Ciliary neurotrophic factor receptor subunit alpha
NCBI Synonym Full Names:	ciliary neurotrophic factor receptor
NCBI Official Symbol:	CNTFR
NCBI Protein Information:	ciliary neurotrophic factor receptor subunit alpha
UniProt Protein Name:	Ciliary neurotrophic factor receptor subunit alpha
Protein Family:	Ciliary neurotrophic factor receptor
UniProt Gene Name:	CNTFR
UniProt Entry Name:	CNTFR_HUMAN

Western blot analysis of extracts of various cell lines, using CNTFR antibody (CAB2700) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Antibodies

Anti-CNTFR Antibody (CAB12424)

CNTFR Antibody (PACO08499)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)