Cell Biology Antibodies 3

Anti-CNTFR Antibody (CAB12424)

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SKU:
CAB12424
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CNTFR Antibody
Antibody SKU:CAB12424
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 90-342 of human CNTFR (NP_671693.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:SH-SY5Y
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 90-342 of human CNTFR (NP_671693.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FHRD SWHL RHQV LLHV GLPP REPV LSCR SNTY PKGF YCSW HLPT PTYI PNTF NVTV LHGS KIMV CEKD PALK NRCH IRYM HLFS TIKY KVSI SVSN ALGH NATA ITFD EFTI VKPD PPEN VVAR PVPS NPRR LEVT WQTP STWP DPES FPLK FFLR YRPL ILDQ WQHV ELSD GTAH TITD AYAG KEYI IQVA AKDN EIGT WSDW SVAA HATP WTEE PRHL TTEA QAAE TTTS TTSS LAPP PTTK ICDP GELG S
Gene ID:1271
Uniprot:P26992
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:40kDa
Observed MW:41kDa
Synonyms:CNTFR
Background:This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
UniProt Protein Function:CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extrinsic to membrane

Molecular Function:cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding

Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation

NCBI Summary:This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
UniProt Code:P26992
NCBI GenInfo Identifier:1352099
NCBI Gene ID:1271
NCBI Accession:P26992.2
UniProt Related Accession:P26992
Molecular Weight:40kDa
NCBI Full Name:Ciliary neurotrophic factor receptor subunit alpha
NCBI Synonym Full Names:ciliary neurotrophic factor receptor
NCBI Official Symbol:CNTFR  
NCBI Protein Information:ciliary neurotrophic factor receptor subunit alpha
UniProt Protein Name:Ciliary neurotrophic factor receptor subunit alpha
Protein Family:Ciliary neurotrophic factor receptor
UniProt Gene Name:CNTFR  
UniProt Entry Name:CNTFR_HUMAN
Anti-CNTFR Antibody (CAB12424)Western blot analysis of extracts of SH-SY5Y cells, using CNTFR antibody (CAB12424) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
Anti-CNTFR Antibody (CAB12424)Immunohistochemistry of paraffin-embedded rat brain using CNTFR antibody (CAB12424) (40x lens).
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