Immunology Antibodies 2
Anti-CNR2 Antibody (CAB1762)
- SKU:
- CAB1762
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CNR2 Antibody |
| Antibody SKU: | CAB1762 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CNR2 (NP_001832.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CNR2 (NP_001832.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEC WVTE IANG SKDG LDSN PMKD YMIL SGPQ KTAV AVLC TLLG LLSA LENV AVLY LILS SHQL RRKP SYLF IGSL AGAD FLAS VVFA CSFV NFHV FHGV |
| Gene ID: | 1269 |
| Uniprot: | P34972 |
| Cellular Location: | Cell membrane, Cell projection, Multi-pass membrane protein, Perikaryon, dendrite |
| Calculated MW: | 39kDa |
| Observed MW: | 45kDa |
| Synonyms: | CNR2, CB-2, CB2, CX5 |
| Background: | The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. |
| UniProt Protein Function: | CNR2: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: extrinsic to internal side of plasma membrane; integral to plasma membrane; dendrite; plasma membrane; perikaryon Molecular Function:cannabinoid receptor activity Biological Process: negative regulation of mast cell activation; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of nitric-oxide synthase activity; negative regulation of inflammatory response; response to amphetamine; response to lipopolysaccharide; immune response; negative regulation of action potential; negative regulation of synaptic transmission, GABAergic; inflammatory response; sensory perception of pain |
| NCBI Summary: | The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P34972 |
| NCBI GenInfo Identifier: | 4502929 |
| NCBI Gene ID: | 1269 |
| NCBI Accession: | NP_001832.1 |
| UniProt Secondary Accession: | P34972,Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0, C6ES44, |
| UniProt Related Accession: | P34972 |
| Molecular Weight: | 39,681 Da |
| NCBI Full Name: | cannabinoid receptor 2 |
| NCBI Synonym Full Names: | cannabinoid receptor 2 (macrophage) |
| NCBI Official Symbol: | CNR2 |
| NCBI Official Synonym Symbols: | CB2; CX5; CB-2 |
| NCBI Protein Information: | cannabinoid receptor 2; testis-dominant CNR2 isoform CB2 |
| UniProt Protein Name: | Cannabinoid receptor 2 |
| UniProt Synonym Protein Names: | CX5 |
| UniProt Gene Name: | CNR2 |
| UniProt Entry Name: | CNR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CNR2 antibody (CAB1762) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using CNR2 antibody (CAB1762) at dilution of 1:150 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using CNR2 antibody (CAB1762) at dilution of 1:150 (40x lens). |
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