Epigenetics & Nuclear Signaling Antibodies 4
Anti-CNOT8 Antibody (CAB8058)
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- SKU:
- CAB8058
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | CNOT8 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8058 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CNOT8 (NP_004770.4). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse liver, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CNOT8 (NP_004770.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPAA LVEN SQVI CEVW ASNL EEEM RKIR EIVL SYSY IAMD TEFP GVVV RPIG EFRS SIDY QYQL LRCN VDLL KIIQ LGLT FTNE KGEY PSGI NTWQ FNFK FNLT EDMY SQDS IDLL ANSG LQFQ KHEE EGID TLHF AELL MTSG VVLC DNVK WLSF HSGY DFGY MVKL LTDS RLPE EEHE FFHI LNLF FPSI YDVK YLMK SCKN LKGG LQEV ADQL DLQR IGRQ HQAG SDSL LTGM AFFR MKEL FFED SIDD AKYC GRLY GLGT GVAQ KQNE DVDS AQEK MSIL AIIN NMQQ |
| Gene ID: | 9337 |
| Uniprot: | Q9UFF9 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 21kDa/27kDa/33kDa |
| Observed MW: | 34kDa |
| Synonyms: | CNOT8, CAF1, CALIF, Caf1b, POP2, hCAF1 |
| Background: |
| UniProt Protein Function: | CNOT8: Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex. Belongs to the CAF1 family. |
| UniProt Protein Details: | Protein type:EC 3.1.13.4 Chromosomal Location of Human Ortholog: 5q31-q33 Cellular Component: intracellular; cytosol; nucleus; CCR4-NOT complex Molecular Function:protein binding; 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; RNA binding; metal ion binding; transcription factor activity Biological Process: regulation of translation; negative regulation of cell proliferation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay |
| UniProt Code: | Q9UFF9 |
| NCBI GenInfo Identifier: | 15213949 |
| NCBI Gene ID: | 9337 |
| NCBI Accession: | Q9UFF9.1 |
| UniProt Secondary Accession: | Q9UFF9,O95709, Q7Z521, Q9H6Y1, B0AZS3, B2RAR8, B7Z8R1 D3DQI8, |
| UniProt Related Accession: | Q9UFF9 |
| Molecular Weight: | 27,415 Da |
| NCBI Full Name: | CCR4-NOT transcription complex subunit 8 |
| NCBI Synonym Full Names: | CCR4-NOT transcription complex, subunit 8 |
| NCBI Official Symbol: | CNOT8 |
| NCBI Official Synonym Symbols: | CAF1; POP2; CALIF; Caf1b; hCAF1 |
| NCBI Protein Information: | CCR4-NOT transcription complex subunit 8; CAF2; CALIFp; CAF1-like protein; CCR4-associated factor 8; PGK promoter directed over production |
| UniProt Protein Name: | CCR4-NOT transcription complex subunit 8 |
| UniProt Synonym Protein Names: | CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b |
| Protein Family: | CCR4-NOT transcription complex |
| UniProt Gene Name: | CNOT8 |
| UniProt Entry Name: | CNOT8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CNOT8 antibody (CAB8058) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human esophagus using CNOT8 antibody (CAB8058) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse stomach using CNOT8 antibody (CAB8058) at dilution of 1:100 (40x lens). |
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