Signal Transduction Antibodies 2
Anti-CNNM4 Antibody (CAB17130)
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- SKU:
- CAB17130
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CNNM4 Antibody |
| Antibody SKU: | CAB17130 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human CNNM4. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse testis, Rat testis |
| Immunogen: | A synthetic peptide of human CNNM4. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 26504 |
| Uniprot: | Q6P4Q7 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 87kDa |
| Synonyms: | CNNM4, ACDP4 |
| Background: | This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. |
| UniProt Protein Function: | CNNM4: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions. May play a role in biomineralization and retinal function. Defects in CNNM4 are the cause of Jalili syndrome (JALIS). A syndrome characterized by the association of cone- rod dystrophy and amelogenesis imperfecta. Belongs to the ACDP family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell cycle regulation; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2q11 Disease: Jalili Syndrome |
| NCBI Summary: | This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q6P4Q7 |
| NCBI GenInfo Identifier: | 224471892 |
| NCBI Gene ID: | 26504 |
| NCBI Accession: | Q6P4Q7.3 |
| UniProt Secondary Accession: | Q6P4Q7,Q53RE5, Q9H9G3, Q9HCI0, Q9NRN1, B7Z1U0, C7SQM3 C7SQM4, C7SQM5, |
| UniProt Related Accession: | Q6P4Q7 |
| Molecular Weight: | 29,485 Da |
| NCBI Full Name: | Metal transporter CNNM4 |
| NCBI Synonym Full Names: | cyclin and CBS domain divalent metal cation transport mediator 4 |
| NCBI Official Symbol: | CNNM4 |
| NCBI Official Synonym Symbols: | ACDP4 |
| NCBI Protein Information: | metal transporter CNNM4 |
| UniProt Protein Name: | Metal transporter CNNM4 |
| UniProt Synonym Protein Names: | Ancient conserved domain-containing protein 4; Cyclin-M4 |
| Protein Family: | Metal transporter |
| UniProt Gene Name: | CNNM4 |
| UniProt Entry Name: | CNNM4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CNNM4 antibody (CAB17130) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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