Signal Transduction Antibodies 2

Anti-CNNM4 Antibody (CAB17130)

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SKU:
CAB17130
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CNNM4 Antibody
Antibody SKU:CAB17130
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human CNNM4.
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse testis, Rat testis
Immunogen:A synthetic peptide of human CNNM4.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:26504
Uniprot:Q6P4Q7
Cellular Location:
Calculated MW:
Observed MW:87kDa
Synonyms:CNNM4, ACDP4
Background:This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta.
UniProt Protein Function:CNNM4: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions. May play a role in biomineralization and retinal function. Defects in CNNM4 are the cause of Jalili syndrome (JALIS). A syndrome characterized by the association of cone- rod dystrophy and amelogenesis imperfecta. Belongs to the ACDP family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell cycle regulation; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q11

Disease: Jalili Syndrome

NCBI Summary:This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010]
UniProt Code:Q6P4Q7
NCBI GenInfo Identifier:224471892
NCBI Gene ID:26504
NCBI Accession:Q6P4Q7.3
UniProt Secondary Accession:Q6P4Q7,Q53RE5, Q9H9G3, Q9HCI0, Q9NRN1, B7Z1U0, C7SQM3 C7SQM4, C7SQM5,
UniProt Related Accession:Q6P4Q7
Molecular Weight:29,485 Da
NCBI Full Name:Metal transporter CNNM4
NCBI Synonym Full Names:cyclin and CBS domain divalent metal cation transport mediator 4
NCBI Official Symbol:CNNM4  
NCBI Official Synonym Symbols:ACDP4  
NCBI Protein Information:metal transporter CNNM4
UniProt Protein Name:Metal transporter CNNM4
UniProt Synonym Protein Names:Ancient conserved domain-containing protein 4; Cyclin-M4
Protein Family:Metal transporter
UniProt Gene Name:CNNM4  
UniProt Entry Name:CNNM4_HUMAN
Anti-CNNM4 Antibody (CAB17130)Western blot analysis of extracts of various cell lines, using CNNM4 antibody (CAB17130) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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