Signal Transduction Antibodies 2

Anti-CNGA2 Antibody (CAB2698)

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SKU:
CAB2698
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CNGA2 Antibody
Antibody SKU:CAB2698
Antibody Size:50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CNGA2
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:10 - 1:50
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant protein of human CNGA2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1260
Uniprot:Q16280
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:76kDa
Observed MW:76kDa
Synonyms:CNGA2, CNCA, CNCA1, CNG2, OCNC1, OCNCALPHA, OCNCa
Background:The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation.
UniProt Protein Function:CNGA2: Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq27

Cellular Component: Golgi membrane; integral to plasma membrane

Molecular Function:calmodulin binding; voltage-gated potassium channel activity; intracellular cGMP activated cation channel activity; cGMP binding; cAMP binding

Biological Process: phototransduction, visible light; regulation of membrane potential; organelle organization and biogenesis; sensory perception of smell

NCBI Summary:The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]
UniProt Code:Q16280
NCBI GenInfo Identifier:119370323
NCBI Gene ID:1260
NCBI Accession:Q16280.2
UniProt Secondary Accession:Q16280,A0AVD0,
UniProt Related Accession:Q16280
Molecular Weight:664
NCBI Full Name:Cyclic nucleotide-gated olfactory channel
NCBI Synonym Full Names:cyclic nucleotide gated channel alpha 2
NCBI Official Symbol:CNGA2  
NCBI Official Synonym Symbols:CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA  
NCBI Protein Information:cyclic nucleotide-gated olfactory channel; CNG-2; CNG channel alpha-2; cyclic nucleotide-gated channel alpha-2; cyclic nucleotide-gated cation channel 2; cyclic-nucleotide-gated cation channel 2; cyclic-nucleotide-gated olfactory channel
UniProt Protein Name:Cyclic nucleotide-gated olfactory channel
UniProt Synonym Protein Names:Cyclic nucleotide-gated cation channel 2; Cyclic nucleotide-gated channel alpha-2; CNG channel alpha-2; CNG-2; CNG2
Protein Family:Cyclic nucleotide-gated olfactory channel
UniProt Gene Name:CNGA2  
UniProt Entry Name:CNGA2_HUMAN
Anti-CNGA2 Antibody (CAB2698)Western blot analysis of extracts of 293T cells, using CNGA2 antibody (CAB2698). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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