Cell Biology Antibodies 7
Anti-CMKLR1 Antibody (CAB16358)
- SKU:
- CAB16358
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-CMKLR1 Antibody |
Antibody SKU: | CAB16358 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CMKLR1 (NP_001135815.1). |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Mouse, Rat |
Positive Samples: | Rat heart |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CMKLR1 (NP_001135815.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | NRLA KTKK PFKI IVTI IITF FLCW CPYH TLNL LELH HTAM PGSV FSLG LPLA TALA IANS CMNP ILYV FMGQ DFKK FKVA LFSR LVNA LSED TGHS SYPS H |
Gene ID: | 1240 |
Uniprot: | Q99788 |
Cellular Location: | Cell membrane, Multi-pass membrane protein |
Calculated MW: | 42kDa |
Observed MW: | 55kDa |
Synonyms: | CMKLR1, CHEMERINR, ChemR23, DEZ, RVER1 |
Background: |
UniProt Protein Function: | CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 12q24.1 Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; protein binding; chemokine receptor activity; receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; regulation of calcium-mediated signaling; positive regulation of fat cell differentiation; immune response; chemotaxis; skeletal development |
UniProt Code: | Q99788 |
NCBI GenInfo Identifier: | 17380487 |
NCBI Gene ID: | 1240 |
NCBI Accession: | Q99788.2 |
UniProt Secondary Accession: | Q99788,O75748, Q3KP37, Q5U0H0, Q99789, A8K6Y5, |
UniProt Related Accession: | Q99788 |
Molecular Weight: | 42,035 Da |
NCBI Full Name: | Chemokine-like receptor 1 |
NCBI Synonym Full Names: | chemokine-like receptor 1 |
NCBI Official Symbol: | CMKLR1 |
NCBI Official Synonym Symbols: | DEZ; RVER1; ChemR23; CHEMERINR |
NCBI Protein Information: | chemokine-like receptor 1; chemerin receptor; resolvin E1 receptor; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez |
UniProt Protein Name: | Chemokine-like receptor 1 |
UniProt Synonym Protein Names: | G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ |
UniProt Gene Name: | CMKLR1 |
UniProt Entry Name: | CML1_HUMAN |
View AllClose