Cell Biology Antibodies 5

Anti-CMKLR1 Antibody (CAB15237)

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SKU:
CAB15237
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CMKLR1 Antibody
Antibody SKU:CAB15237
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CMKLR1 (NP_001135815.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:LO2, Mouse brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CMKLR1 (NP_001135815.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NRLA KTKK PFKI IVTI IITF FLCW CPYH TLNL LELH HTAM PGSV FSLG LPLA TALA IANS CMNP ILYV FMGQ DFKK FKVA LFSR LVNA LSED TGHS SYPS H
Gene ID:1240
Uniprot:Q99788
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:42kDa
Observed MW:45kDa
Synonyms:CMKLR1, CHEMERINR, ChemR23, DEZ, RVER1
Background:
UniProt Protein Function:CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function:G-protein coupled receptor activity; protein binding; chemokine receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; regulation of calcium-mediated signaling; positive regulation of fat cell differentiation; immune response; chemotaxis; skeletal development

UniProt Code:Q99788
NCBI GenInfo Identifier:17380487
NCBI Gene ID:1240
NCBI Accession:Q99788.2
UniProt Secondary Accession:Q99788,O75748, Q3KP37, Q5U0H0, Q99789, A8K6Y5,
UniProt Related Accession:Q99788
Molecular Weight:42,035 Da
NCBI Full Name:Chemokine-like receptor 1
NCBI Synonym Full Names:chemokine-like receptor 1
NCBI Official Symbol:CMKLR1  
NCBI Official Synonym Symbols:DEZ; RVER1; ChemR23; CHEMERINR  
NCBI Protein Information:chemokine-like receptor 1; chemerin receptor; resolvin E1 receptor; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez
UniProt Protein Name:Chemokine-like receptor 1
UniProt Synonym Protein Names:G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ
UniProt Gene Name:CMKLR1  
UniProt Entry Name:CML1_HUMAN
Anti-CMKLR1 Antibody (CAB15237)Western blot analysis of extracts of various cell lines, using CMKLR1 antibody (CAB15237) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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