Cell Biology Antibodies 4
Anti-CMAS Antibody (CAB13752)
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- SKU:
- CAB13752
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CMAS Antibody |
| Antibody SKU: | CAB13752 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human CMAS (NP_061156.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HT-29, 293T, HepG2, DU145, Mouse heart, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human CMAS (NP_061156.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDSV EKGA ATSV SNPR GRPS RGRP PKLQ RNSR GGQG RGVE KPPH LAAL ILAR GGSK GIPL KNIK HLAG VPLI GWVL RAAL DSGA FQSV WVST DHDE IENV AKQF GAQV HRRS SEVS KDSS TSLD AIIE FLNY HNEV DIVG NIQA TSPC LHPT DLQK VAEM IREE GYDS VFSV VRRH QFRW SEIQ KGVR EVTE PLNL NPAK RPRR QDWD GELY ENGS FYFA KRHL IEMG YLQG GKMA YYEM RAEH SVDI DVDI DWPI AEQR VLR |
| Gene ID: | 55907 |
| Uniprot: | Q8NFW8 |
| Cellular Location: | Nucleus |
| Calculated MW: | 29kDa/48kDa |
| Observed MW: | 48kDa |
| Synonyms: | CMAS, CSS |
| Background: | This gene encodes an enzyme that converts N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc). This process is important in the formation of sialylated glycoprotein and glycolipids. This modification plays a role in cell-cell communications and immune responses. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CMAS: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Belongs to the CMP-NeuNAc synthase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.7.43; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Transferase Chromosomal Location of Human Ortholog: 12p12.1 Cellular Component: cytosol; membrane; nucleoplasm; nucleus Molecular Function:N-acylneuraminate cytidylyltransferase activity |
| NCBI Summary: | This gene encodes an enzyme that converts N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc). This process is important in the formation of sialylated glycoprotein and glycolipids. This modification plays a role in cell-cell communications and immune responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q8NFW8 |
| NCBI GenInfo Identifier: | 68059539 |
| NCBI Gene ID: | 55907 |
| NCBI Accession: | Q8NFW8.2 |
| UniProt Secondary Accession: | Q8NFW8,Q96AX5, Q9NQZ0, |
| UniProt Related Accession: | Q8NFW8 |
| Molecular Weight: | 29,561 Da |
| NCBI Full Name: | N-acylneuraminate cytidylyltransferase |
| NCBI Synonym Full Names: | cytidine monophosphate N-acetylneuraminic acid synthetase |
| NCBI Official Symbol: | CMAS |
| NCBI Official Synonym Symbols: | CSS |
| NCBI Protein Information: | N-acylneuraminate cytidylyltransferase |
| UniProt Protein Name: | N-acylneuraminate cytidylyltransferase |
| UniProt Synonym Protein Names: | CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase |
| Protein Family: | N-acylneuraminate cytidylyltransferase |
| UniProt Gene Name: | CMAS |
| UniProt Entry Name: | NEUA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CMAS Antibody (CAB13752) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CMAS antibody (CAB13752) at dilution of 1:150 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using CMAS antibody (CAB13752) at dilution of 1:150 (40x lens). |
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