Immunology Antibodies 2
Anti-CMA1 Antibody (CAB5668)
- SKU:
- CAB5668
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CMA1 Antibody |
| Antibody SKU: | CAB5668 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 81-247 of human CMA1 (NP_001827.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, A-431, HT-29, MCF7, Mouse lung, Mouse small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 81-247 of human CMA1 (NP_001827.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ITEE EDTW QKLE VIKQ FRHP KYNT STLH HDIM LLKL KEKA SLTL AVGT LPFP SQFN FVPP GRMC RVAG WGRT GVLK PGSD TLQE VKLR LMDP QACS HFRD FDHN LQLC VGNP RKTK SAFK GDSG GPLL CAGV AQGI VSYG RSDA KPPA VFTR ISHY RPWI NQIL QAN |
| Gene ID: | 1215 |
| Uniprot: | P23946 |
| Cellular Location: | Cytoplasmic granule, Secreted |
| Calculated MW: | 14kDa/27kDa |
| Observed MW: | 27kDa |
| Synonyms: | CMA1, CYH, MCT1, chymase |
| Background: | This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. |
| UniProt Protein Function: | CMA1: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Belongs to the peptidase S1 family. Granzyme subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; EC 3.4.21.39; Protease Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: extracellular matrix; extracellular space; extracellular region; intracellular Molecular Function:serine-type peptidase activity; serine-type endopeptidase activity; peptide binding Biological Process: interleukin-1 beta biosynthetic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of angiogenesis; cellular protein metabolic process; regulation of inflammatory response; midbrain development; protein processing; proteolysis; angiotensin maturation |
| NCBI Summary: | This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P23946 |
| NCBI GenInfo Identifier: | 126825 |
| NCBI Gene ID: | 1215 |
| NCBI Accession: | P23946.1 |
| UniProt Secondary Accession: | P23946,Q16018, Q3SY36, Q3SY37, Q9UDH5, B5BUM8, |
| UniProt Related Accession: | P23946 |
| Molecular Weight: | |
| NCBI Full Name: | Chymase |
| NCBI Synonym Full Names: | chymase 1, mast cell |
| NCBI Official Symbol: | CMA1 |
| NCBI Official Synonym Symbols: | CYH; MCT1; chymase |
| NCBI Protein Information: | chymase; alpha-chymase; chymase, heart; chymase, mast cell; mast cell protease I; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I |
| UniProt Protein Name: | Chymase |
| UniProt Synonym Protein Names: | Alpha-chymase; Mast cell protease I |
| Protein Family: | Chymase |
| UniProt Gene Name: | CMA1 |
| UniProt Entry Name: | CMA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CMA1 antibody (CAB5668) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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