Name: Anti-CLTC Antibody (CAB7886)
Brand: Autophagy Antibodies
SKU: CAB7886
Availability: OutOfStock

Antibody Name:	Anti-CLTC Antibody
Antibody SKU:	CAB7886
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human CLTC

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, BT-474, Mouse brain, Mouse lung, Rat brain

Immunogen:	A synthetic peptide of human CLTC
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	1213
Uniprot:	Q00610
Cellular Location:	Cytoplasmic side, Cytoplasmic vesicle membrane, Melanosome, Membrane, Peripheral membrane protein, coated pit
Calculated MW:	187kDa/191kDa
Observed MW:	180kDa

Synonyms:	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc
Background:	Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.

UniProt Protein Function:	CLTC: a major protein component of the cytoplasmic face of coated vesicles and coated pits. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Vesicle Chromosomal Location of Human Ortholog: 17q23.1 Cellular Component: clathrin coat; clathrin-coated vesicle; cytosol; endosome; extracellular matrix; focal adhesion; lysosome; membrane; plasma membrane; protein complex; spindle; trans-Golgi network membrane Molecular Function:clathrin light chain binding; double-stranded RNA binding; protein binding; protein kinase binding; RNA binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin cage assembly; microtubule-based movement; mitotic cell cycle; osteoblast differentiation; receptor internalization; receptor-mediated endocytosis; retrograde transport, endosome to Golgi; transferrin transport; Wnt receptor signaling pathway, planar cell polarity pathway
NCBI Summary:	Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
UniProt Code:	Q00610
NCBI GenInfo Identifier:	1705916
NCBI Gene ID:	1213
NCBI Accession:	Q00610.5
UniProt Secondary Accession:	Q00610,Q6N0A0, Q86TF2, D3DU00,
UniProt Related Accession:	Q00610
Molecular Weight:	192kDa
NCBI Full Name:	Clathrin heavy chain 1
NCBI Synonym Full Names:	clathrin heavy chain
NCBI Official Symbol:	CLTC
NCBI Official Synonym Symbols:	Hc; CHC; CHC17; CLH-17; CLTCL2
NCBI Protein Information:	clathrin heavy chain 1
UniProt Protein Name:	Clathrin heavy chain 1
UniProt Synonym Protein Names:	Clathrin heavy chain on chromosome 17; CLH-17
Protein Family:	Clathrin
UniProt Gene Name:	CLTC

	Western blot analysis of extracts of various cell lines, using CLTC antibody (CAB7886) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded human stomach using CLTC antibody (CAB7886) (40x lens).
	Immunohistochemistry of paraffin-embedded rat kidney using CLTC antibody (CAB7886) (40x lens).