Autophagy Antibodies
Anti-CLTC Antibody (CAB12423)
- SKU:
- CAB12423
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Description
| Antibody Name: | Anti-CLTC Antibody |
| Antibody SKU: | CAB12423 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1451-1675 of human CLTC (NP_004850.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, NIH/3T3, Mouse brain, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1451-1675 of human CLTC (NP_004850.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YLRS VQNH NNKS VNES LNNL FITE EDYQ ALRT SIDA YDNF DNIS LAQR LEKH ELIE FRRI AAYL FKGN NRWK QSVE LCKK DSLY KDAM QYAS ESKD TELA EELL QWFL QEEK RECF GACL FTCY DLLR PDVV LETA WRHN IMDF AMPY FIQV MKEY LTKV DKLD ASES LRKE EEQA TETQ PIVY GQPQ LMLT AGPS VAVP PQAP FGYG YTAP PYGQ PQPG FGYS M |
| Gene ID: | 1213 |
| Uniprot: | Q00610 |
| Cellular Location: | Cytoplasmic side, Cytoplasmic vesicle membrane, Melanosome, Membrane, Peripheral membrane protein, coated pit |
| Calculated MW: | 187kDa/191kDa |
| Observed MW: | 191kDa |
| Synonyms: | CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc |
| Background: | Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. |
| UniProt Protein Function: | CLTC: a major protein component of the cytoplasmic face of coated vesicles and coated pits. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Vesicle Chromosomal Location of Human Ortholog: 17q23.1 Cellular Component: clathrin coat; clathrin-coated vesicle; cytosol; endosome; extracellular matrix; focal adhesion; lysosome; membrane; plasma membrane; protein complex; spindle; trans-Golgi network membrane Molecular Function:clathrin light chain binding; double-stranded RNA binding; protein binding; protein kinase binding; RNA binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin cage assembly; microtubule-based movement; mitotic cell cycle; osteoblast differentiation; receptor internalization; receptor-mediated endocytosis; retrograde transport, endosome to Golgi; transferrin transport; Wnt receptor signaling pathway, planar cell polarity pathway |
| NCBI Summary: | Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q00610 |
| NCBI GenInfo Identifier: | 1705916 |
| NCBI Gene ID: | 1213 |
| NCBI Accession: | Q00610.5 |
| UniProt Secondary Accession: | Q00610,Q6N0A0, Q86TF2, D3DU00, |
| UniProt Related Accession: | Q00610 |
| Molecular Weight: | 192kDa |
| NCBI Full Name: | Clathrin heavy chain 1 |
| NCBI Synonym Full Names: | clathrin heavy chain |
| NCBI Official Symbol: | CLTC |
| NCBI Official Synonym Symbols: | Hc; CHC; CHC17; CLH-17; CLTCL2 |
| NCBI Protein Information: | clathrin heavy chain 1 |
| UniProt Protein Name: | Clathrin heavy chain 1 |
| UniProt Synonym Protein Names: | Clathrin heavy chain on chromosome 17; CLH-17 |
| Protein Family: | Clathrin |
| UniProt Gene Name: | CLTC |
 | Western blot analysis of extracts of various cell lines, using CLTC antibody (CAB12423) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of HeLa cells using CLTC antibody (CAB12423) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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