Cell Biology Antibodies 13

Anti-CLSPN Antibody (CAB17202)

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SKU:
CAB17202
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CLSPN Antibody
Antibody SKU:CAB17202
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CLSPN (NP_001177410.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HepG2, Jurkat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CLSPN (NP_001177410.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SVPK SLSS DSTL LLFK DSSS KMGY FPTE EKSE TDEN SGKQ PSKL DEDD SCSL LTKE SSHN SSFE LIGS TIPS YQPC NRQT GRGT SFFP TAGG FRSP SPGL F
Gene ID:63967
Uniprot:Q9HAW4
Cellular Location:
Calculated MW:151kDa
Observed MW:275kDa
Anti-CLSPN Antibody (CAB17202)Western blot - CLSPN Polyclonal Antibody (CAB17202)
Synonyms:CLSPN, claspin
Background:The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:claspin: required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. Interacts with CHEK1 when phosphorylated. Interacts with ATR and RAD9A and these interactions are slightly reduced during checkpoint activation. Interacts with BRCA1 and this interaction increases during checkpoint activation.
UniProt Protein Details:

Protein type:Actin-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: cytoplasm; nucleoplasm

Molecular Function:protein binding

Biological Process: activation of protein kinase activity; cell structure disassembly during apoptosis; DNA damage checkpoint; DNA replication; G2/M transition DNA damage checkpoint; mitotic cell cycle DNA replication checkpoint; peptidyl-serine phosphorylation

NCBI Summary:The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Code:Q9HAW4
NCBI GenInfo Identifier:299522984
NCBI Gene ID:63967
NCBI Accession:NP_001177410.1
UniProt Secondary Accession:Q9HAW4,Q1RMC6, Q2KHM3, Q5VYG0, Q6P6H5, Q8IWI1, A6NFL4
UniProt Related Accession:Q9HAW4
Molecular Weight:150,368 Da
NCBI Full Name:claspin isoform 2
NCBI Synonym Full Names:claspin
NCBI Official Symbol:CLSPN  
NCBI Protein Information:claspin
UniProt Protein Name:Claspin
Protein Family:Claspin
UniProt Gene Name:CLSPN  
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