Signal Transduction Antibodies 3

Anti-CLPB Antibody (CAB9130)

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SKU:
CAB9130
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CLPB Antibody
Antibody SKU:CAB9130
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 458-707 of human CLPB (NP_110440.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, MCF7, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 458-707 of human CLPB (NP_110440.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KAHP DVLT IMLQ LFDE GRLT DGKG KTID CKDA IFIM TSNV ASDE IAQH ALQL RQEA LEMS RNRI AENL GDVQ ISDK ITIS KNFK ENVI RPIL KAHF RRDE FLGR INEI VYFL PFCH SELI QLVN KELN FWAK RAKQ RHNI TLLW DREV ADVL VDGY NVHY GARS IKHE VERR VVNQ LAAA YEQD LLPG GCTL RITV EDSD KQLL KSPE LPSP QAEK RLPK LRLE IIDK DSKT RRLD IRAP LHPE KVCN TI
Gene ID:81570
Uniprot:Q9H078
Cellular Location:Mitochondrion
Calculated MW:57kDa/72kDa/74kDa/75kDa/78kDa
Observed MW:79kDa
Synonyms:CLPB, ANKCLB, HSP78, MEGCANN, MGCA7, SKD3
Background:This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CLPB: May function as a regulatory ATPase and be related to secretion/protein trafficking process. Belongs to the clpA/clpB family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial

Chromosomal Location of Human Ortholog: 11q13.4

Molecular Function:protein binding

Disease: 3-methylglutaconic Aciduria With Cataracts, Neurologic Involvement, And Neutropenia

NCBI Summary:This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
UniProt Code:Q9H078
NCBI GenInfo Identifier:25009267
NCBI Gene ID:81570
NCBI Accession:Q9H078.1
UniProt Secondary Accession:Q9H078,Q8ND11, Q9H8Y0, B4DXJ7, B4DXP7, B4DXW4, E7EWN6 F8W7P6,
UniProt Related Accession:Q9H078
Molecular Weight:57,664 Da
NCBI Full Name:Caseinolytic peptidase B protein homolog
NCBI Synonym Full Names:ClpB homolog, mitochondrial AAA ATPase chaperonin
NCBI Official Symbol:CLPB  
NCBI Official Synonym Symbols:SKD3; HSP78; MGCA7; ANKCLB; MEGCANN  
NCBI Protein Information:caseinolytic peptidase B protein homolog
UniProt Protein Name:Caseinolytic peptidase B protein homolog
UniProt Synonym Protein Names:Suppressor of potassium transport defect 3
Protein Family:Chaperone protein
UniProt Gene Name:CLPB  
UniProt Entry Name:CLPB_HUMAN
Anti-CLPB Polyclonal Antibody (CAB9130)Western blot analysis of extracts of various cell lines, using CLPB antibody (CAB9130) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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