Cell Biology Antibodies 12
Anti-CLNS1A Antibody (CAB9739)
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- SKU:
- CAB9739
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- FC
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CLNS1A Antibody |
| Antibody SKU: | CAB9739 |
| Antibody Size: | 100uL |
| Application: | WB IHC FC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human CLNS1A |
| Application: | WB IHC FC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:20 - 1:50 FC 1:20 - 1:50 |
| Reactivity: | Human |
| Positive Samples: | 293T, DU145, Jurkat, HeLa |
| Immunogen: | A synthetic Peptide of human CLNS1A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1207 |
| Uniprot: | P54105 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton, cytosol |
| Calculated MW: | 26kDa |
| Observed MW: | 38kDa |
| Synonyms: | CLNS1A, CLCI, CLNS1B, ICln |
| Background: | This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family. |
| UniProt Protein Details: | Protein type:Channel, chloride Chromosomal Location of Human Ortholog: 11q13.5-q14 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: spliceosomal snRNP biogenesis |
| NCBI Summary: | This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P54105 |
| NCBI GenInfo Identifier: | 1708393 |
| NCBI Gene ID: | 1207 |
| NCBI Accession: | P54105.1 |
| UniProt Secondary Accession: | P54105,Q0VDK6, Q9NRD2, Q9NRD3, B2RCS9, |
| UniProt Related Accession: | P54105 |
| Molecular Weight: | 26,215 Da |
| NCBI Full Name: | Methylosome subunit pICln |
| NCBI Synonym Full Names: | chloride nucleotide-sensitive channel 1A |
| NCBI Official Symbol: | CLNS1A |
| NCBI Official Synonym Symbols: | CLCI; ICln; CLNS1B |
| NCBI Protein Information: | methylosome subunit pICln |
| UniProt Protein Name: | Methylosome subunit pICln |
| UniProt Synonym Protein Names: | Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln |
| UniProt Gene Name: | CLNS1A |
| UniProt Entry Name: | ICLN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLNS1A antibody (CAB9739) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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