Cell Biology Antibodies 10
Anti-CLK1 Antibody (CAB6887)
(No reviews yet)
Write a Review
- SKU:
- CAB6887
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CLK1 Antibody |
| Antibody SKU: | CAB6887 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CLK1 (NP_004062.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CLK1 (NP_004062.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRHS KRTY CPDW DDKD WDYG KWRS SSSH KRRK RSHS SAQE NKRC KYNH SKMC DSHY LESR SINE KDYH SRRY IDEY RNDY TQGC EPGH RQRD HESR YQNH SSKS SGRS GRSS YKSK HRIH HSTS HRRS HG |
| Gene ID: | 1195 |
| Uniprot: | P49759 |
| Cellular Location: | Nucleus |
| Calculated MW: | 16kDa/57kDa/61kDa |
| Observed MW: | 55kDa |
| Synonyms: | CLK1, CLK, CLK/STY, STY |
| Background: | This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CLK1: a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May play a role in regulating RNA splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; EC 2.7.12.1; Kinase, protein; CMGC group; CLK family Chromosomal Location of Human Ortholog: 2q33 Cellular Component: cytoplasm; nucleus Molecular Function:protein serine/threonine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding Biological Process: cell proliferation; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; regulation of RNA splicing; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation |
| NCBI Summary: | This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] |
| UniProt Code: | P49759 |
| NCBI GenInfo Identifier: | 206729857 |
| NCBI Gene ID: | 1195 |
| NCBI Accession: | P49759.2 |
| UniProt Secondary Accession: | P49759,Q0P694, Q8N5V8, B4DFW7, |
| UniProt Related Accession: | P49759 |
| Molecular Weight: | 484 |
| NCBI Full Name: | Dual specificity protein kinase CLK1 |
| NCBI Synonym Full Names: | CDC-like kinase 1 |
| NCBI Official Symbol: | CLK1 |
| NCBI Official Synonym Symbols: | CLK; STY; CLK/STY |
| NCBI Protein Information: | dual specificity protein kinase CLK1; CDC28/CDC2-like kinase; protein tyrosine kinase STY |
| UniProt Protein Name: | Dual specificity protein kinase CLK1 |
| UniProt Synonym Protein Names: | CDC-like kinase 1 |
| Protein Family: | Dual specificity protein kinase |
| UniProt Gene Name: | CLK1 |
| UniProt Entry Name: | CLK1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLK1 antibody (CAB6887) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
View AllClose
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक