Name: Anti-CLINT1 Antibody (CAB4332)
Brand: Cell Biology Antibodies 9
SKU: CAB4332
Availability: OutOfStock

Antibody Name:	Anti-CLINT1 Antibody
Antibody SKU:	CAB4332
Antibody Size:	100uL
Application:	WB IHC
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthetic Peptide of human CLINT1

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:1000 IHC 1:20 - 1:50
Reactivity:	Human
Positive Samples:	HL-60

Immunogen:	A synthetic Peptide of human CLINT1
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	9685
Uniprot:	Q14677
Cellular Location:	Cytoplasm, Cytoplasmic vesicle, Membrane, Peripheral membrane protein, clathrin-coated vesicle, perinuclear region
Calculated MW:	68kDa/70kDa
Observed MW:	64kDa

Synonyms:

CLINT1, CLINT, ENTH, EPN4, EPNR

Background:

This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants.

UniProt Protein Function:	ENTH: Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. Belongs to the epsin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; membrane; clathrin-coated vesicle; perinuclear region of cytoplasm; cytosol Molecular Function:protein binding; clathrin binding; lipid binding Biological Process: clathrin cage assembly; endocytosis; post-Golgi vesicle-mediated transport Disease: Schizophrenia 1
NCBI Summary:	This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
UniProt Code:	Q14677
NCBI GenInfo Identifier:	41016993
NCBI Gene ID:	9685
NCBI Accession:	Q14677.1
UniProt Related Accession:	Q14677
Molecular Weight:
NCBI Full Name:	Clathrin interactor 1
NCBI Synonym Full Names:	clathrin interactor 1
NCBI Official Symbol:	CLINT1
NCBI Official Synonym Symbols:	ENTH; EPN4; EPNR; CLINT
NCBI Protein Information:	clathrin interactor 1
UniProt Protein Name:	Clathrin interactor 1
UniProt Synonym Protein Names:	Clathrin-interacting protein localized in the trans-Golgi region; Clint; Enthoprotin; Epsin-4; Epsin-related protein; EpsinR
Protein Family:	Enterotoxin
UniProt Gene Name:	CLINT1
UniProt Entry Name:	EPN4_HUMAN

Western blot analysis of extracts of HL-60 cells, using CLINT1 antibody (CAB4332). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Antibodies

CLINT1 Antibody (PACO08466)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)