Cell Biology Antibodies 9
Anti-CLINT1 Antibody (CAB4332)
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- SKU:
- CAB4332
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CLINT1 Antibody |
| Antibody SKU: | CAB4332 |
| Antibody Size: | 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human CLINT1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:20 - 1:50 |
| Reactivity: | Human |
| Positive Samples: | HL-60 |
| Immunogen: | A synthetic Peptide of human CLINT1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9685 |
| Uniprot: | Q14677 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Membrane, Peripheral membrane protein, clathrin-coated vesicle, perinuclear region |
| Calculated MW: | 68kDa/70kDa |
| Observed MW: | 64kDa |
| Synonyms: | CLINT1, CLINT, ENTH, EPN4, EPNR |
| Background: | This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | ENTH: Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. Belongs to the epsin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; membrane; clathrin-coated vesicle; perinuclear region of cytoplasm; cytosol Molecular Function:protein binding; clathrin binding; lipid binding Biological Process: clathrin cage assembly; endocytosis; post-Golgi vesicle-mediated transport Disease: Schizophrenia 1 |
| NCBI Summary: | This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q14677 |
| NCBI GenInfo Identifier: | 41016993 |
| NCBI Gene ID: | 9685 |
| NCBI Accession: | Q14677.1 |
| UniProt Related Accession: | Q14677 |
| Molecular Weight: | |
| NCBI Full Name: | Clathrin interactor 1 |
| NCBI Synonym Full Names: | clathrin interactor 1 |
| NCBI Official Symbol: | CLINT1 |
| NCBI Official Synonym Symbols: | ENTH; EPN4; EPNR; CLINT |
| NCBI Protein Information: | clathrin interactor 1 |
| UniProt Protein Name: | Clathrin interactor 1 |
| UniProt Synonym Protein Names: | Clathrin-interacting protein localized in the trans-Golgi region; Clint; Enthoprotin; Epsin-4; Epsin-related protein; EpsinR |
| Protein Family: | Enterotoxin |
| UniProt Gene Name: | CLINT1 |
| UniProt Entry Name: | EPN4_HUMAN |
 | Western blot analysis of extracts of HL-60 cells, using CLINT1 antibody (CAB4332). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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