Signal Transduction Antibodies 2
Anti-CLIC3 Antibody (CAB15347)
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- SKU:
- CAB15347
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CLIC3 Antibody |
| Antibody SKU: | CAB15347 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 87-236 of human CLIC3 (NP_004660.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse lung, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 87-236 of human CLIC3 (NP_004660.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPPD FPSL APRY RESN TAGN DVFH KFSA FIKN PVPA QDEA LYQQ LLRA LARL DSYL RAPL EHEL AGEP QLRE SRRR FLDG DRLT LADC SLLP KLHI VDTV CAHF RQAP IPAE LRGV RRYL DSAM QEKE FKYT CPHS AEIL AAYR PAVH PR |
| Gene ID: | 9022 |
| Uniprot: | O95833 |
| Cellular Location: | Cytoplasm, Membrane, Nucleus, Single-pass membrane protein |
| Calculated MW: | 26kDa |
| Observed MW: | 27kDa |
| Synonyms: | CLIC3 |
| Background: | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. |
| UniProt Protein Function: | CLIC3: Can insert into membranes and form chloride ion channels. May participate in cellular growth control. Belongs to the chloride channel CLIC family. |
| UniProt Protein Details: | Protein type:Channel, chloride; Membrane protein, integral Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: cytoplasm; nucleus Molecular Function:chloride channel activity; glutathione transferase activity; protein binding; voltage-gated ion channel activity Biological Process: chloride transport; glutathione metabolic process; signal transduction |
| NCBI Summary: | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95833 |
| NCBI GenInfo Identifier: | 46397812 |
| NCBI Gene ID: | 9022 |
| NCBI Accession: | O95833.2 |
| UniProt Secondary Accession: | O95833,Q5SPZ7, |
| UniProt Related Accession: | O95833 |
| Molecular Weight: | 26,648 Da |
| NCBI Full Name: | Chloride intracellular channel protein 3 |
| NCBI Synonym Full Names: | chloride intracellular channel 3 |
| NCBI Official Symbol: | CLIC3 |
| NCBI Protein Information: | chloride intracellular channel protein 3 |
| UniProt Protein Name: | Chloride intracellular channel protein 3 |
| Protein Family: | Chloride intracellular channel protein |
| UniProt Gene Name: | CLIC3 |
| UniProt Entry Name: | CLIC3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLIC3 antibody (CAB15347) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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