Signal Transduction Antibodies 3
Anti-CLIC1 Antibody (CAB6363)
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- SKU:
- CAB6363
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-CLIC1 Antibody |
| Antibody SKU: | CAB6363 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-241 of human CLIC1 (NP_001279.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Jurkat, HeLa, HepG2, Mouse kidney, Mouse lung, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-241 of human CLIC1 (NP_001279.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NVTT VDTK RRTE TVQK LCPG GQLP FLLY GTEV HTDT NKIE EFLE AVLC PPRY PKLA ALNP ESNT AGLD IFAK FSAY IKNS NPAL NDNL EKGL LKAL KVLD NYLT SPLP EEVD ETSA EDEG VSQR KFLD GNEL TLAD CNLL PKLH IVQV VCKK YRGF TIPE AFRG VHRY LSNA YARE EFAS TCPD DEEI ELAY EQVA KALK |
| Gene ID: | 1192 |
| Uniprot: | O00299 |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus, Nucleus membrane, Single-pass membrane protein |
| Calculated MW: | 26kDa |
| Observed MW: | 27kDa |
| Synonyms: | CLIC1, CL1C1, G6, NCC27 |
| Background: | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. |
| UniProt Protein Function: | Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. |
| NCBI Summary: | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00299 |
| NCBI GenInfo Identifier: | 12643390 |
| NCBI Gene ID: | 1192 |
| NCBI Accession: | O00299.4 |
| UniProt Secondary Accession: | O00299,Q15089, Q502X1, |
| UniProt Related Accession: | O00299 |
| Molecular Weight: | 26,923 Da |
| NCBI Full Name: | Chloride intracellular channel protein 1 |
| NCBI Synonym Full Names: | chloride intracellular channel 1 |
| NCBI Official Symbol: | CLIC1 |
| NCBI Official Synonym Symbols: | G6; NCC27 |
| NCBI Protein Information: | chloride intracellular channel protein 1 |
| UniProt Protein Name: | Chloride intracellular channel protein 1 |
| UniProt Synonym Protein Names: | Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC |
| Protein Family: | Chloride intracellular channel protein |
| UniProt Gene Name: | CLIC1 |
| UniProt Entry Name: | CLIC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLIC1 antibody (CAB6363) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CLIC1 antibody (CAB6363) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using CLIC1 antibody (CAB6363). Blue: DAPI for nuclear staining. |
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