Immunology Antibodies 3
Anti-CLEC7A Antibody (CAB9883)
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- SKU:
- CAB9883
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CLEC7A Antibody |
| Antibody SKU: | CAB9883 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLEC7A (NP_922938.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | H-460, SGC-7901, HL-60, Mouse spleen, Mouse thymus, Mouse liver, Mouse lung, Rat spleen |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLEC7A (NP_922938.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LEDS VTPT KAVK TTGV LSSP CPPN WIIY EKSC YLFS MSLN SWDG SKRQ CWQL GSNL LKID SSNE LGFI VKQV SSQP DNSF WIGL SRPQ TEVP WLWE DGST FSSN LFQI RTTA TQEN PSPN CVWI HVSV IYDQ LCSV PSYS ICEK KFSM |
| Gene ID: | 64581 |
| Uniprot: | Q9BXN2 |
| Cellular Location: | Cell membrane, Cytoplasm, Single-pass type II membrane protein |
| Calculated MW: | 5kDa/8kDa/13-27kDa |
| Observed MW: | 31kDa |
| Synonyms: | CLEC7A, BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2 |
| Background: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1, 3-linked and beta-1, 6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. |
| UniProt Protein Function: | dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.2 Cellular Component: cytoplasm; plasma membrane; integral to membrane Molecular Function:metal ion binding; carbohydrate binding; MHC protein binding; pattern recognition receptor activity Biological Process: T cell activation; innate immune response; cell recognition; phagocytosis, recognition; carbohydrate mediated signaling; pattern recognition receptor signaling pathway; defense response to protozoan; inflammatory response Disease: Candidiasis, Familial, 4; Aspergillosis, Susceptibility To |
| NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BXN2 |
| NCBI GenInfo Identifier: | 74752433 |
| NCBI Gene ID: | 64581 |
| NCBI Accession: | Q9BXN2.1 |
| UniProt Secondary Accession: | Q9BXN2,Q6IPS7, Q96D32, Q96DR9, Q96LD3, Q96PA4, Q96PA5 Q96PA6, B2R861, B7Z494, B7Z5A9, B7Z5B9, |
| UniProt Related Accession: | Q9BXN2 |
| Molecular Weight: | 13,138 Da |
| NCBI Full Name: | C-type lectin domain family 7 member A |
| NCBI Synonym Full Names: | C-type lectin domain family 7, member A |
| NCBI Official Symbol: | CLEC7A |
| NCBI Official Synonym Symbols: | BGR; CANDF4; DECTIN1; CLECSF12 |
| NCBI Protein Information: | C-type lectin domain family 7 member A; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 |
| UniProt Protein Name: | C-type lectin domain family 7 member A |
| UniProt Synonym Protein Names: | Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1 |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC7A |
| UniProt Entry Name: | CLC7A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLEC7A antibody (CAB9883) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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