Anti-CLEC4E Antibody (CAB20156)

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SKU:
CAB20156
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MINCLE
Synonyms:
CLECSF9

Description

Product Name:CLEC4E Rabbit pAb
Product Code:CAB20156
Size:50uL, 100uL
Synonyms:MINCLE, CLECSF9
Applications:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CLEC4E.
Applications:WB
Recommended Dilutions:WB 1:1000 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse spleen, Rat spleen
Immunogen:Recombinant protein of human CLEC4E.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:26253
Uniprot:Q9ULY5
Calculated MW:25kDa
Observed MW:27KDa
UniProt Protein Function:CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function:carbohydrate binding; receptor activity

Biological Process: defense response to bacterium; innate immune response; positive regulation of cytokine secretion; stimulatory C-type lectin receptor signaling pathway; T cell differentiation during immune response

NCBI Summary:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
UniProt Code:Q9ULY5
NCBI GenInfo Identifier:7657333
NCBI Gene ID:26253
NCBI Accession:NP_055173.1
UniProt Secondary Accession:Q9ULY5,B2R6Q6,
UniProt Related Accession:Q9ULY5
Molecular Weight:25,073 Da
NCBI Full Name:C-type lectin domain family 4 member E
NCBI Synonym Full Names:C-type lectin domain family 4 member E
NCBI Official Symbol:CLEC4E  
NCBI Official Synonym Symbols:MINCLE; CLECSF9  
NCBI Protein Information:C-type lectin domain family 4 member E
UniProt Protein Name:C-type lectin domain family 4 member E
UniProt Synonym Protein Names:C-type lectin superfamily member 9; Macrophage-inducible C-type lectin
Protein Family:C-type lectin domain family
UniProt Gene Name:CLEC4E  
UniProt Entry Name:CLC4E_HUMAN
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