Name: Anti-CLEC4C Antibody (CAB13702)
Brand: Immunology Antibodies 1
SKU: CAB13702
Availability: OutOfStock

Antibody Name:	Anti-CLEC4C Antibody
Antibody SKU:	CAB13702
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 45-213 of human CLEC4C (NP_569708.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	K-562, Mouse spleen

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 45-213 of human CLEC4C (NP_569708.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NFMY SKTV KRLS KLRE YQQY HPSL TCVM EGKD IEDW SCCP TPWT SFQS SCYF ISTG MQSW TKSQ KNCS VMGA DLVV INTR EEQD FIIQ NLKR NSSY FLGL SDPG GRRH WQWV DQTP YNEN VTFW HSGE PNNL DERC AIIN FRSS EEWG WNDI HCHV PQKS ICKM KKIY I
Gene ID:	170482
Uniprot:	Q8WTT0
Cellular Location:	Membrane, Single-pass type II membrane protein
Calculated MW:	21kDa/25kDa
Observed MW:	38kDa

Synonyms:

CLEC4C, BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL, PRO34150

Background:

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene.

UniProt Protein Function:	NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: axon; extracellular region Molecular Function:growth factor activity; receptor binding Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway Disease: Hirschsprung Disease, Susceptibility To, 1
NCBI Summary:	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q8WTT0
NCBI GenInfo Identifier:	18466806
NCBI Gene ID:	170482
NCBI Accession:	NP_569708
UniProt Related Accession:	Q8WTT0
Molecular Weight:
NCBI Full Name:	C-type lectin domain family 4 member C isoform 1
NCBI Synonym Full Names:	C-type lectin domain family 4 member C
NCBI Official Symbol:	CLEC4C
NCBI Official Synonym Symbols:	DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150
NCBI Protein Information:	C-type lectin domain family 4 member C
UniProt Protein Name:	Neurturin
Protein Family:	Neurturin
UniProt Gene Name:	NRTN
UniProt Entry Name:	NRTN_HUMAN

Western blot analysis of extracts of various cell lines, using CLEC4C antibody (CAB13702) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Antibodies

Human CD303 Monoclonal Antibody (FITC Conjugated) [201A](AGEL1816)

Human CD303 Monoclonal Antibody (PE Conjugated) [201A](AGEL1817)

Human CD303 Monoclonal Antibody (APC Conjugated) [201A](AGEL1818)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)