Cell Biology Antibodies 1
Anti-CLEC2D Antibody (CAB10421)
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- SKU:
- CAB10421
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CLEC2D Antibody |
| Antibody SKU: | CAB10421 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-154 of human CLEC2D (NP_037401.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, HL-60, LO2, U-87MG, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-154 of human CLEC2D (NP_037401.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RANC HQEP SVCL QAAC PESW IGFQ RKCF YFSD DTKN WTSS QRFC DSQD ADLA QVES FQEL NFLL RYKG PSDH WIGL SREQ GQPW KWIN GTEW TRQ |
| Gene ID: | 29121 |
| Uniprot: | Q9UHP7 |
| Cellular Location: | Cell membrane, Cell surface, Endoplasmic reticulum, Single-pass type II membrane protein |
| Calculated MW: | 10kDa/14kDa/17kDa/21kDa/22kDa |
| Observed MW: | 38kDa |
| Synonyms: | CLEC2D, CLAX, LLT1, OCIL |
| Background: | This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. |
| UniProt Protein Function: | CLEC2D: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cell surface; membrane; endoplasmic reticulum; integral to plasma membrane Molecular Function:transmembrane receptor activity; carbohydrate binding Biological Process: cell surface receptor linked signal transduction |
| NCBI Summary: | This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q9UHP7 |
| NCBI GenInfo Identifier: | 74753331 |
| NCBI Gene ID: | 29121 |
| NCBI Accession: | Q9UHP7.1 |
| UniProt Secondary Accession: | Q9UHP7,Q6YID5, Q8WUP7, Q9HD37, Q9HD38, D6CI39, D6CI40 D6CI41, |
| UniProt Related Accession: | Q9UHP7 |
| Molecular Weight: | 10,823 Da |
| NCBI Full Name: | C-type lectin domain family 2 member D |
| NCBI Synonym Full Names: | C-type lectin domain family 2, member D |
| NCBI Official Symbol: | CLEC2D |
| NCBI Official Synonym Symbols: | CLAX; LLT1; OCIL |
| NCBI Protein Information: | C-type lectin domain family 2 member D; LLT-1; C-type lectin related f; lectin-like transcript 1; lectin-like NK cell receptor; osteoclast inhibitory lectin; C-type lectin superfamily 2, member D |
| UniProt Protein Name: | C-type lectin domain family 2 member D |
| UniProt Synonym Protein Names: | Lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; Osteoclast inhibitory lectin |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC2D |
| UniProt Entry Name: | CLC2D_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLEC2D antibody (CAB10421) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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