Immunology Antibodies 3

Anti-CLEC1B Antibody (CAB9971)

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SKU:
CAB9971
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-CLEC1B Antibody
Antibody SKU:CAB9971
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human CLEC1B (NP_001092901.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HepG2, HL-60, Mouse thymus, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human CLEC1B (NP_001092901.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVMQ RNYL QGEN ENRT GTLQ QLAK RFCQ YVVK QSEL KGTF KGHK CSPC DTNW RYYG DSCY GFFR HNLT WEES KQYC TDMN ATLL KIDN RNIV EYIK ARTH LIRW VGLS RQKS NEVW KWED GSVI SENM FEFL EDGK GNMN CAYF HNGK MHPT FCEN KHYL MCER KAGM TKVD QLP
Gene ID:51266
Uniprot:Q9P126
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:23kDa/26kDa
Observed MW:27kDa
Synonyms:CLEC1B, 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721
Background:
UniProt Protein Function:CLEC1B: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: integral to plasma membrane

Molecular Function:protein binding; transmembrane receptor activity; carbohydrate binding

Biological Process: cell surface receptor linked signal transduction; defense response; platelet formation

NCBI Summary:Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
UniProt Code:Q9P126
NCBI GenInfo Identifier:134035066
NCBI Gene ID:51266
NCBI Accession:Q9P126.2
UniProt Secondary Accession:Q9P126,Q6UWX7, Q8NHR6,
UniProt Related Accession:Q9P126
Molecular Weight:23,096 Da
NCBI Full Name:C-type lectin domain family 1 member B
NCBI Synonym Full Names:C-type lectin domain family 1, member B
NCBI Official Symbol:CLEC1B  
NCBI Official Synonym Symbols:CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik  
NCBI Protein Information:C-type lectin domain family 1 member B; CLEC-2; C-type lectin-like receptor 2; C-type lectin-like receptor-2
UniProt Protein Name:C-type lectin domain family 1 member B
UniProt Synonym Protein Names:C-type lectin-like receptor 2; CLEC-2
Protein Family:C-type lectin domain family
UniProt Gene Name:CLEC1B  
UniProt Entry Name:CLC1B_HUMAN
Anti-CLEC1B Polyclonal Antibody (CAB9971)Western blot analysis of extracts of various cell lines, using CLEC1B antibody (CAB9971) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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