Cell Biology Antibodies 10

Anti-CLEC12A Antibody (CAB6250)

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SKU:
CAB6250
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CLEC12A Antibody
Antibody SKU:CAB6250
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 66-265 of human CLEC12A (NP_612210.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 66-265 of human CLEC12A (NP_612210.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VTLK IEMK KMNK LQNI SEEL QRNI SLQL MSNM NISN KIRN LSTT LQTI ATKL CREL YSKE QEHK CKPC PRRW IWHK DSCY FLSD DVQT WQES KMAC AAQN ASLL KINN KNAL EFIK SQSR SYDY WLGL SPEE DSTR GMRV DNII NSSA WVIR NAPD LNNM YCGY INRL YVQY YHCT YKKR MICE KMAN PVQL GSTY FREA
Gene ID:160364
Uniprot:Q5QGZ9
Cellular Location:Cell membrane, Single-pass type II membrane protein
Calculated MW:8kDa/24kDa/27kDa/30kDa/32kDa
Observed MW:24kDa
Synonyms:CLEC12A, CD371, CLL-1, CLL1, DCAL-2, MICL
Background:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
UniProt Protein Function:CLEC12A: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

NCBI Summary:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]
UniProt Code:Q5QGZ9
NCBI GenInfo Identifier:308153619
NCBI Gene ID:160364
NCBI Accession:Q5QGZ9.3
UniProt Secondary Accession:Q5QGZ9,Q6P4H1, Q6RH77, Q6RH78, Q8TDQ6, B2RA16,
UniProt Related Accession:Q5QGZ9
Molecular Weight:
NCBI Full Name:C-type lectin domain family 12 member A
NCBI Synonym Full Names:C-type lectin domain family 12 member A
NCBI Official Symbol:CLEC12A  
NCBI Official Synonym Symbols:CLL1; MICL; CD371; CLL-1; DCAL-2  
NCBI Protein Information:C-type lectin domain family 12 member A
UniProt Protein Name:C-type lectin domain family 12 member A
UniProt Synonym Protein Names:C-type lectin-like molecule 1; CLL-1; Dendritic cell-associated lectin 2; DCAL-2; Myeloid inhibitory C-type lectin-like receptor; MICL
Protein Family:C-type lectin domain family
UniProt Gene Name:CLEC12A  
Anti-CLEC12A Antibody (CAB6250)Western blot analysis of extracts of K-562 cells, using CLEC12A antibody (CAB6250) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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