Cell Biology Antibodies 8

Anti-CLEC11A Antibody (CAB3634)

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SKU:
CAB3634
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CLEC11A Antibody
Antibody SKU:CAB3634
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-323 of human CLEC11A (NP_002966.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A-549, Jurkat, 22Rv1
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-323 of human CLEC11A (NP_002966.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ARGA EREW EGGW GGAQ EEER EREA LMLK HLQE ALGL PAGR GDEN PAGT VEGK EDWE MEED QGEE EEEE ATPT PSSG PSPS PTPE DIVT YILG RLAG LDAG LHQL HVRL HALD TRVV ELTQ GLRQ LRNA AGDT RDAV QALQ EAQG RAER EHGR LEGC LKGL RLGH KCFL LSRD FEAQ AAAQ ARCT ARGG SLAQ PADR QQME ALTR YLRA ALAP YNWP VWLG VHDR RAEG LYLF ENGQ RVSF FAWH RSPR PELG AQPS ASPH PLSP DQPN GGTL ENCV AQAS DDGS WWDH DCQR RLYY VCEF PF
Gene ID:6320
Uniprot:Q9Y240
Cellular Location:Cytoplasm, Secreted
Calculated MW:35kDa
Observed MW:46kDa
Synonyms:CLEC11A, CLECSF3, LSLCL, P47, SCGF
Background:This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined.
UniProt Protein Function:CLEC11A: Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function:growth factor activity; carbohydrate binding

Biological Process: positive regulation of cell proliferation

UniProt Code:Q9Y240
NCBI GenInfo Identifier:34223087
NCBI Gene ID:
NCBI Accession:Q9Y240.1
Molecular Weight:
NCBI Full Name:C-type lectin domain family 11 member A
UniProt Protein Name:C-type lectin domain family 11 member A
UniProt Synonym Protein Names:C-type lectin superfamily member 3; Lymphocyte secreted C-type lectin; Stem cell growth factor; p47
UniProt Gene Name:CLEC11A  
UniProt Entry Name:CLC11_HUMAN
Anti-CLEC11A Antibody (CAB3634)Western blot analysis of extracts of various cell lines, using CLEC11A antibody (CAB3634) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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