Immunology Antibodies 1
Anti-CLEC10A Antibody (CAB11859)
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- SKU:
- CAB11859
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CLEC10A Antibody |
| Antibody SKU: | CAB11859 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human CLEC10A (NP_878910.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, K-562, Raji, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human CLEC10A (NP_878910.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FQNS KFQR DLVT LRTD FSNF TSNT VAEI QALT SQGS SLEE TIAS LKAE VEGF KQER QAGV SELQ EHTT QKAH LGHC PHCP SVCV PVHS EMLL RVQQ LVQD LKKL TCQV ATLN NNAS TEGT C |
| Gene ID: | 10462 |
| Uniprot: | Q8IUN9 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 28kDa/32kDa/35kDa |
| Observed MW: | 38kDa |
| Synonyms: | CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL |
| Background: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | CLEC10A: Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: integral to membrane; plasma membrane Molecular Function:carbohydrate binding Biological Process: innate immune response; endocytosis |
| NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IUN9 |
| NCBI GenInfo Identifier: | 59797948 |
| NCBI Gene ID: | 10462 |
| NCBI Accession: | Q8IUN9.1 |
| UniProt Related Accession: | Q8IUN9 |
| Molecular Weight: | |
| NCBI Full Name: | C-type lectin domain family 10 member A |
| NCBI Synonym Full Names: | C-type lectin domain containing 10A |
| NCBI Official Symbol: | CLEC10A |
| NCBI Official Synonym Symbols: | HML; MGL; HML2; CD301; CLECSF13; CLECSF14 |
| NCBI Protein Information: | C-type lectin domain family 10 member A |
| UniProt Protein Name: | C-type lectin domain family 10 member A |
| UniProt Synonym Protein Names: | C-type lectin superfamily member 14; Macrophage lectin 2; CD_antigen: CD301 |
| UniProt Gene Name: | CLEC10A |
| UniProt Entry Name: | CLC10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLEC10A antibody (CAB11859) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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