Immunology Antibodies 1

Anti-CLEC10A Antibody (CAB11859)

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SKU:
CAB11859
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CLEC10A Antibody
Antibody SKU:CAB11859
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human CLEC10A (NP_878910.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, K-562, Raji, Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human CLEC10A (NP_878910.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FQNS KFQR DLVT LRTD FSNF TSNT VAEI QALT SQGS SLEE TIAS LKAE VEGF KQER QAGV SELQ EHTT QKAH LGHC PHCP SVCV PVHS EMLL RVQQ LVQD LKKL TCQV ATLN NNAS TEGT C
Gene ID:10462
Uniprot:Q8IUN9
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:28kDa/32kDa/35kDa
Observed MW:38kDa
Synonyms:CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL
Background:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.
UniProt Protein Function:CLEC10A: Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function:carbohydrate binding

Biological Process: innate immune response; endocytosis

NCBI Summary:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8IUN9
NCBI GenInfo Identifier:59797948
NCBI Gene ID:10462
NCBI Accession:Q8IUN9.1
UniProt Related Accession:Q8IUN9
Molecular Weight:
NCBI Full Name:C-type lectin domain family 10 member A
NCBI Synonym Full Names:C-type lectin domain containing 10A
NCBI Official Symbol:CLEC10A  
NCBI Official Synonym Symbols:HML; MGL; HML2; CD301; CLECSF13; CLECSF14  
NCBI Protein Information:C-type lectin domain family 10 member A
UniProt Protein Name:C-type lectin domain family 10 member A
UniProt Synonym Protein Names:C-type lectin superfamily member 14; Macrophage lectin 2; CD_antigen: CD301
UniProt Gene Name:CLEC10A  
UniProt Entry Name:CLC10_HUMAN
Anti-CLEC10A Antibody (CAB11859)Western blot analysis of extracts of various cell lines, using CLEC10A antibody (CAB11859) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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