Cell Biology Antibodies 5
Anti-CLDN8 Antibody (CAB14470)
- SKU:
- CAB14470
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-CLDN8 Antibody |
Antibody SKU: | CAB14470 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-81 of human CLDN8 (NP_955360.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Mouse |
Positive Samples: |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-81 of human CLDN8 (NP_955360.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | QWRV SAFI ENNI VVFE NFWE GLWM NCVR QANI RMQC KIYD SLLA LSPD LQAA R |
Gene ID: | 9073 |
Uniprot: | P56748 |
Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
Calculated MW: | 24kDa |
Observed MW: | Refer to Figures |
Synonyms: | CLDN8, HEL-S-79, claudin-8 |
Background: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. |
UniProt Protein Function: | Claudin-8: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: endoplasmic reticulum; plasma membrane; tight junction Molecular Function:identical protein binding; protein binding Biological Process: calcium-independent cell-cell adhesion |
NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010] |
UniProt Code: | P56748 |
NCBI GenInfo Identifier: | 6685307 |
NCBI Gene ID: | 9073 |
NCBI Accession: | P56748.1 |
UniProt Secondary Accession: | P56748,Q53EX7, D3DSE3, |
UniProt Related Accession: | P56748 |
Molecular Weight: | 24,845 Da |
NCBI Full Name: | Claudin-8 |
NCBI Synonym Full Names: | claudin 8 |
NCBI Official Symbol: | CLDN8 |
NCBI Official Synonym Symbols: | HEL-S-79 |
NCBI Protein Information: | claudin-8 |
UniProt Protein Name: | Claudin-8 |
Protein Family: | Claudin |
UniProt Gene Name: | CLDN8 |
UniProt Entry Name: | CLD8_HUMAN |
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